Results 181 to 190 of about 47,769 (294)

Rare dysfunctional SCN2A variants are associated with malformation of cortical development

Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.
Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot, Christopher H. Thompson, Susan Sotardi, Jinan Jiang, Marina Trivisano, Simona Balestrini, D. Isum Ward, Natalie Ginn, Brunetta Guaragni, Laura Malerba, Angeliki Vakrinou, Mia Sherer, Ingo Helbig, Ala Somarowthu, Sanjay M. Sisodiya, Roy Ben‐Shalom, Renzo Guerrini, Nicola Specchio, Alfred L. George Jr, Ethan M. Goldberg   +19 more
wiley   +1 more source

Emerging contaminants: assessing the release of pharmaceuticals via managed aquifer recharge. [PDF]

Environ Sci Pollut Res Int
Dibyanshu D, Scheytt T.
europepmc   +1 more source

Interactions Between Carbamazepine and Birth Control Pills

, 1989
Daniel Rapport, Joseph R. Calabrese
openalex   +1 more source

EEG signal dimension is an index of seizure propensity and antiseizure medication effects in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Variability in the frequency, timing, and pattern of seizures may influence the assessment of the effect of antiseizure medications (ASMs) when measuring seizure frequency, especially in patients with infrequent seizures. A low seizure rate is an exclusion criterion for enrollment of patients with epilepsy in clinical trials and ...
Massimo Rizzi, Peter J. West, Annamaria Vezzani, Karen S. Wilcox, Alessandro Giuliani   +4 more
wiley   +1 more source

Preformulation Study of Carbamazepine Orally Disintegrating Tablets for Pediatric Patients Using Direct Compression and the SeDeM Diagram Tool: A Quality by Design Approach. [PDF]

Pharmaceutics
Canadell-Heredia R, Rouaz-El-Hajoui K, Franco-Piedrahita N, Pérez-Lozano P, Suñé-Pou M, Suñé-Negre JM, García-Montoya E.   +6 more
europepmc   +1 more source

Changes in cortical delta power during chronic invasive epilepsy monitoring

Epilepsia, EarlyView.
Abstract Objective Cortical delta band (1–4 Hz) activity is considered a biomarker for states of altered consciousness, with increased delta power observed during anesthesia, sleep, coma, and delirium. The current study sought to characterize delta power following electrode implantation with respect to patient demographics and clinical characteristics ...
Emily R. Dappen, Bryan M. Krause, Rashmi N. Mueller, Matthew I. Banks, Kirill V. Nourski   +4 more
wiley   +1 more source

Carbamazepine-induced bullous eruption or bullous pemphigoid?

, 1984
Arieh Ingber, Marcelo H. Grunwald, Eleasar J. Feuerman   +2 more
openalex   +1 more source

Rethinking preclinical models in drug‐resistant epilepsy: From seizures to side effects all at once

British Journal of Pharmacology, EarlyView.
Emilio Russo
wiley   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source