Results 181 to 190 of about 61,637 (294)

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Co-crystallization in Antiepileptic Drugs: A Path Toward Better Therapeutic Outcomes. [PDF]

Cureus
Patil B, Surana S, Shirkhedkar A.
europepmc   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

Oxcarbazepine Induced Rhabdomyolysis and Acute Kidney Injury: A Case Report. [PDF]

Case Rep Nephrol
Yavuz Ileri S, Can Usta N.
europepmc   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications. 1. Use of the EEG in drug development and characteristics of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof‐of‐principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalography (EEG) response (PPR) as a surrogate for seizures, is currently the only human model that allows POP trials of investigational compounds after ...
Dorothée Kasteleijn‐Nolst Trenité, Wolfgang Löscher   +1 more
wiley   +1 more source

Second‐line pharmacological treatment strategies for trigeminal neuralgia: A retrospective comparison of lacosamide, gabapentin and baclofen

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background and Objectives Carbamazepine is commonly used as the first‐line treatment for trigeminal neuralgia, but therapeutic failure due to adverse effects is frequent. While various second‐line alternatives have been suggested, there is limited evidence directly comparing these options.
Albert Muñoz‐Vendrell, Paloma Valín‐Villanueva, Raquel Tena‐Cucala, Sergio Campoy, Sergio Martínez‐Yélamos, Mariano Huerta‐Villanueva   +5 more
wiley   +1 more source

Comparative efficacy and safety of alternatives to sodium valproate in the management of bipolar affective disorder in people of child-bearing age: a narrative review by the European Society of Clinical Pharmacy's mental health specialist interest group. [PDF]

Int J Clin Pharm
Fitzgerald I, Bayraktar I, Eiden B, Gittins R, Magni E, Humbert-Claude M, Molitschnig LT, Darm P, Waksmundzka-Walczuk A, Riesenhuber N, Stuhec M, Tašková I, Hahn M.   +12 more
europepmc   +1 more source

Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions

Epilepsia, 2014
U. Amstutz, N. Shear, M. Rieder, Soomi Hwang, Vincent Fung, Hidefumi Nakamura, M. Connolly, S. Ito, B. Carleton   +8 more
semanticscholar   +1 more source

Threshold‐dependent association between non‐rapid eye movement obstructive sleep apnea and interictal epileptiform discharges: A hospital study

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary Obstructive sleep apnea frequently coexists with epilepsy, potentially influencing its pathophysiology. However, the effect of obstructive sleep apnea severity on interictal epileptiform discharges is not well understood. To explore this, we studied 108 Asian patients with epilepsy who underwent single‐night polysomnography.
Meina Wu, Pei Xue, Jinzhu Yan, Christian Benedict   +3 more
wiley   +1 more source

Efficacy and safety of lacosamide in patients with trigeminal neuralgia: an 8-week pilot dose-escalation study. [PDF]

J Oral Facial Pain Headache
Lappichetpaiboon P, Tiamkao S, Ruangsri S, Paphangkorakit J, Pitiphat W, Jorns TP.   +5 more
europepmc   +1 more source