Results 61 to 70 of about 77,203 (291)

The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients

Balkan Journal of Medical Genetics, 2016
The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD, Milovanovic JR, Radovanovic M, Radosavljevic I, Obradovic S, Jankovic S, Milovanovic D, Djordjevic N   +7 more
doaj   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates. We evaluated the safety and efficacy of lacosamide for neonatal seizures. Methods This 10‐center, retrospective study of neonates with seizures
Alexandra Santana Almansa, Jessica R. Landers, Nicholas S. Abend, Giulia M. Benedetti, Catherine J. Chu, Andrew T. Knox, Shavonne Massey, Steffany Moen, Andrea C. Pardo, Arnold Sansevere, Renée A. Shellhaas, Cameron Thomas, Tammy Tsuchida, Sonya Wang, Bo Zhang, Janet S. Soul   +15 more
wiley   +1 more source

Postictal self‐removal of intracerebral electrodes during stereoelectroencephalography monitoring: A case series

Epileptic Disorders, EarlyView.
Abstract Epilepsy surgery remains the most effective treatment for focal drug‐resistant epilepsy, and stereoelectroencephalography (SEEG) is increasingly used to define the epileptogenic‐zone network (EZN) and guide curative or palliative interventions.
Ionuț‐Flavius Bratu, Romain Carron, Julia Makhalova, Stanislas Lagarde, Fabrice Bartolomei   +4 more
wiley   +1 more source

An Epileptic Girl With Erotomania Using Carbamazepine|Resistant to Treatment and Challenge of Starting Clozapine. [PDF]

Clin Case Rep
ABSTRACT The management of treatment‐resistant erotomania in patients with epilepsy requires a cautious pharmacological approach. This case demonstrates that replacing carbamazepine with valproic acid enabled the safe initiation of clozapine, resulting in resolution of erotomanic delusions while maintaining effective seizure control.
Roham F, Mohammadghasemi S, Bidaki R, Hasanabadi I, Shamsi A.   +4 more
europepmc   +2 more sources

Executive functions and self‐limited epilepsy with centro‐temporal spikes: A scoping review

Epileptic Disorders, EarlyView.
Abstract Executive functions are a set of high‐level cognitive processes necessary for planning, organization, decision‐making, self‐control, and attention, and are carried out in the anterior frontal lobes. An impairment in executive functioning might present as difficulties in planning and organizing activities, in attention and concentration, in ...
Edoardo Fino, Martina Calì, Sara Senese, Simona Pellacani, Viola Margheri, Chiara Pecini, Carmen Barba   +6 more
wiley   +1 more source

Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS

Регуляторные исследования и экспертиза лекарственных средств, 2018
Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use ...
T. A. Rodina, E. S. Melnikov, A. V. Sokolov, A. B. Prokofiev, V. V. Arkhipov, G. V. Adamov, D. L. Pozdnyakov, Yu. V. Olefir   +7 more
doaj  

Uptake of carbamazepine by rhizomes and endophytic bacteria of Phragmites australis

Frontiers in Plant Science, 2015
Carbamazepine is an antiepileptic and mood-stabilizing drug which is used widely in Europe and North America. In the environment, it is found as a persistent and recalcitrant contaminant, being one of the most prominent hazardous pharmaceuticals and ...
A. Sauvêtre, P. Schröder
semanticscholar   +1 more source

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source