A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain
Neurobiology of Disease, 2012 Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh +7 more
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Application of experimental design in examination of the dissolution rate of carbamazepine from formulations: Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis [PDF]
Journal of the Serbian Chemical Society, 2015 Poor solubility is one of the key reasons for the poor bioavailability of these drugs. This paper displays a formulation of a solid surfactant system with carbamazepine, in order to increase its dissolution rate.
Krstić Marko +4 more
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Anticonvulsants in the treatment of aggression in the demented elderly : an update
, 2009 Introduction Complex psychopathological and behavioral symptoms, such as delusions and aggression against care providers, are often the primary cause of acute hospital admissions of elderly patients to emergency units and psychiatric departments.
Ana Gonzalez-Pinto +18 more
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A Pharmacokinetic Evaluation of a Pectin-Based Oral Multiparticulate Matrix Carrier of Carbamazepine
Advances in Pharmacological and Pharmaceutical Sciences, 2021 Background. Carbamazepine is a drug used in the treatment of neurological disorders such as epilepsy. However, due to its erratic absorption, oral bioavailability is often poor.
Seth Kwabena Amponsah +4 more
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Toxics, 2022 Carbamazepine is the main option used as a preventive medication to treat bipolar disorder when there is no response to lithium. Carbamazepine toxicity is defined as serum levels greater than 12 μg/mL, with severe toxicity occurring over 40 μg/mL ...
Lucia Fernández-López +5 more
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Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline
Case Reports in Neurological Medicine, 2012 A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that
A. Bruce Janati +2 more
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Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana +3 more
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Epilepsia, 2018 We assessed the efficacy and safety of once‐daily eslicarbazepine acetate in comparison with twice‐daily (BID) controlled‐release carbamazepine (carbamazepine‐CR) monotherapy in newly diagnosed focal epilepsy patients.
E. Trinka +7 more
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Assessment of adherence to carbamazepine using plasma and saliva samples, a study from Jordan
HeliyonBackground: The measurement of carbamazepine levels in a biological sample is required to guide dosing, and prevent toxicity, and can be useful to assess medication adherence. Aim: The primary aim of the presented study is to analyze carbamazepine levels
Ghaith M. Al-Taani +3 more
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Carbamazepine kinetics in cardiac patients before and during amiodarone
Arquivos de Neuro-Psiquiatria, 1994 Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy ...
Silmara A.O. Leite +4 more
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