Integrated Transcriptomic and Metabolomic Analysis Elucidates the Impact of Acute Ammonia Stress on Carbohydrate and Lipid Metabolic Pathways in Yellow Catfish (Pelteobagrus fulvidraco) [PDF]
Aquaculture NutritionAmmonia stress (AS) constitutes a significant environmental challenge that impedes aquaculture development. In this investigation, histomorphology assessments, physiological, and biochemical parameter analyses, and multiomics approaches were employed to ...
Xue Li +4 more
doaj +2 more sources
ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment [PDF]
, 2011 Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence.
Benga, L. +6 more
core +15 more sources
Adaptation of the carbamoyl-phosphate synthetase enzyme in an extremophile fish [PDF]
Royal Society Open Science, 2020 Tetrapods and fish have adapted distinct carbamoyl-phosphate synthase (CPS) enzymes to initiate the ornithine urea cycle during the detoxification of nitrogenous wastes.
Lewis J. White +5 more
doaj +1 more source
Lysinuric protein intolerance mimicking N-acetylglutamate synthase deficiency in a nine-year-old boy
Molecular Genetics and Metabolism Reports, 2021 We report a 9-year-old boy with lysinuric protein intolerance (LPI). He had developmental delay, short stature, failure to thrive, high-protein food aversion, hypothyroidism, growth hormone deficiency, features of hemophagocytic lymphohistiocytosis (HLH),
Sarah Al-Qattan +2 more
doaj +1 more source
Kinetic properties of carbamoyl-phosphate synthase (ammonia) and ornithine carbamoyltransferase in permeabilized mitochondria [PDF]
Biochemical Journal, 1992 Previous studies using intact rat liver mitochondria have shown that the soluble matrix enzymes carbamoyl-phosphate synthase (ammonia) (CPS) and ornithine carbamoyltransferase (OCT) display some kinetic properties which would not be observed if they were homogeneously distributed in the matrix.
N S, Cohen +3 more
openaire +2 more sources
JIMD Reports, 2023 N‐acetyl glutamate synthase (NAGS) deficiency (OMIM #: 237310) is a rare urea cycle disorder that usually presents early in life with hyperammonemia.
Lea Abou Haidar +5 more
doaj +1 more source
Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment. [PDF]
PLoS ONE, 2016 Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are potential resources for the regeneration of defective organs, including the liver. However, some obstacles must be overcome before this becomes reality.
Daihachiro Tomotsune +7 more
doaj +1 more source
Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience
Journal of Pediatric Research, 2023 Aim:Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes ...
Ayşe Ergül Bozacı +7 more
doaj +1 more source
Heliyon, 2023 Urea cycle is an important metabolic process that initiates in liver mitochondria and converts ammonia to urea. The impairment of ammonia detoxification, both primary and secondary causes, lead to hyperammonemia, a life-threatening condition affecting to
Sumate Ampawong +6 more
doaj +1 more source
Inhibition of carbamoyl-phosphate synthase (ammonia) by Tris and Hepes. Effect on Ka for N-acetylglutamate [PDF]
Biochemical Journal, 1987 The apparent Ka for N-acetylglutamate of rat liver carbamoyl-phosphate synthase is 11 microM in phosphate buffer, a value 10-fold lower than reported in other buffer systems. Tris and Hepes inhibit competitively with N-acetylglutamate. The proportion of carbamoyl-phosphate synthase in the active enzyme-acetylglutamate complex in vivo may be higher than
P, Lund, D, Wiggins
openaire +2 more sources