Results 31 to 40 of about 2,442 (103)

Conversion of pyridoxal to pyridoxamine with NH3 and H2 on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

The FEBS Journal, Volume 292, Issue 12, Page 3041-3055, June 2025.
Recent studies show that Ni0 catalyzes amino acid synthesis from 2‐oxoacids via reductive amination. We show that the cofactor pyridoxal is reductively aminated to pyridoxamine, the NH2‐transferring intermediate of transaminations, with NH3 (~ 5 mm) and H2 (5 bar) on Ni0 catalysts within hours in water under serpentinizing hydrothermal vent conditions (
Manon Laura Schlikker, Max Brabender, Loraine Schwander, Carolina Garcia Garcia, Maximillian Burmeister, Sabine Metzger, Joseph Moran, William F. Martin   +7 more
wiley   +1 more source

How eriophyid mites shape metal metabolism in leaf galls on Tilia cordata

New Phytologist, Volume 246, Issue 5, Page 2222-2242, June 2025.
Summary Metal metabolism in plant–galler interactions is largely unknown. We hypothesise that the mites manipulate metal distribution by sequestration of excessive levels and differential regulation of metalloproteins to support the main functions of gall‐nutrition, protection and microenvironment.
Filis Morina, Anđela Kuvelja, Dennis Brückner, Miloš Mojović, Đura Nakarada, Syed Nadeem Hussain Bokhari, Bojan Vujić, Gerald Falkenberg, Hendrik Küpper   +8 more
wiley   +1 more source

Regulation of Arginine Metabolism and Ethanol Tolerance in Saccharomyces cerevisiae by BTN2

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
The impact of BTN2 modified strains on key metabolites, enzymes, and gene expression in the arginine metabolic pathway was investigated. BTN2 knock out strain was found to reduce arginine uptake and promote arginine and urea degradation. BTN2 was found to enhance ethanol tolerance and reduce ethanol‐induced oxidative damage.
Ting Xia, Keiwei Chen, Huqi Zhou, Tangchao Chen, Wenjing Lin, Gongnian Xiao, Ruosi Fang   +6 more
wiley   +1 more source

Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment

European Journal of Immunology, Volume 55, Issue 4, April 2025.
Metabolic antagonism in the TME suppresses CD8+ T cell function by depleting essential nutrients and generating toxic byproducts. Metabolic symbiosis between tumor cells and TAMs fosters an immunosuppressive microenvironment. Disrupting metabolic interactions can overcome immune suppression, boost antitumor immunity, and enhance immunotherapy efficacy.
Fengxia Gao, Rushil Shah, Gang Xin, Ruoning Wang   +3 more
wiley   +1 more source

Emergency Management of Intoxication‐Type Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT In many intoxication‐type inherited metabolic disorders, the accumulation of the toxic chemical can cause acute life‐threatening emergencies. Sometimes this is the inevitable consequence of a severe metabolic defect, but it is often triggered by catabolism.
J. Dexter Tarr, Andrew A. M. Morris
wiley   +1 more source

Diagnostic and management challenges of a case of N-acetylglutamate synthase deficiency in a resource-limited healthcare setting in Tanzania: a case report. [PDF]

BMC Pediatr
Thaver S, Ebrahim M, Noorani M, Alimohamed ZM, Edward K, Furia F, Kwayu J, Fidaali Z, Abdallah Y.   +8 more
europepmc   +1 more source

Case Report: Carglumic acid accelerates ammonia clearance in a neonate with methylmalonic acidemia. [PDF]

Front Pediatr
Ma Q, Luo Y, Zhang X, Xu L, Shi D, Shi M, Yu D.   +6 more
europepmc   +1 more source

Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review. [PDF]

Biochem Soc Trans
Alberti M, Miggiano R.
europepmc   +1 more source

Gastric Bypass Associated Hyperammonemia (GaBHA): A Case Study, Scoping Review of the Literature, and Proposed New Pathophysiologic Mechanism. [PDF]

Metabolites
Fenves AZ, Hatipoglu D, Robinson JC, Rothkopf MM.   +3 more
europepmc   +1 more source

ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance. [PDF]

Hepatol Commun
Ming Z, Luo T, Zou Z, Luo W, Hu X, Chen L, Zhou J, Liu X, Liu M, Li J, Luo J, Ma D, Liu S, Luo Z.   +13 more
europepmc   +1 more source