Results 41 to 50 of about 4,935 (147)

Seizures and electroencephalographic findings in inborn errors of metabolism: Clues to differential diagnosis in the neonatal period, infancy, childhood and adolescence, and review of the literature

Epileptic Disorders, Volume 27, Issue 5, Page 745-802, October 2025.
Abstract Although inborn errors of metabolism (IEM) are a rare cause of epilepsy, seizures are a common presentation in these disorders. Seizures in IEM are frequently refractory to conventional anti‐seizure medication and might warrant initiation of specific treatments based on vitamins or dietary modifications or provision of alternative substrates ...
D. Kapoor, S. Sharma, A. Kaminska, R. Nabbout, N. Chemaly, M. Schiff, P. De Lonlay, M. Eisermann   +7 more
wiley   +1 more source

Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation [PDF]

, 2010
Objective Mitochondrial disturbances of energy-generating systems in childhood are a heterogeneous group of disorders. The aim of this multi-site survey was to characterise the natural course of a novel mitochondrial disease with ATP synthase deficiency ...
Bodamer, O, Freisinger, P, Hansikova, H, Honzik, T, Houstek, J, Huemer, M, Jesina, P, Kmoch, S, Koch, J, Kostkova, O, Magner, M, Mayr, JA, Sperl, W, Tesarova, M, Van Coster, Rudy, Zeman, J   +15 more
core   +2 more sources

Impact of Advances in Anion Exchange Membranes and Ionomers on Alkaline Fuel Cells

Chemistry – An Asian Journal, Volume 20, Issue 18, September 15, 2025.
Advances in anion exchange membranes (AEMs) and ionomer design have propelled alkaline fuel cells toward unprecedented performance, with peak power densities exceeding 3.5 W cm⁻2. This review highlights how molecular‐level innovations— stable hydrocarbon backbones, robust cationic groups, and pH‐gradient‐enabled bipolar interfaces—enable durable, high ...
Zhongyang Wang, Shrihari Sankarasubramanian, Jianping Chen, Vijay K. Ramani   +3 more
wiley   +1 more source

Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung, Dany Perocheau, Roopkatha Ghosh, Stephen L. Hart, Julien Baruteau   +4 more
wiley   +1 more source

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers [PDF]

, 2013
Background Trypanosomatids of the genera Angomonas and Strigomonas live in a mutualistic association characterized by extensive metabolic cooperation with obligate endosymbiotic Betaproteobacteria.
Alves, João M.P., Buck, Gregory A., Camargo, Erney P., Costa-Martins, André G., da Silva, Flávia Maia, Klein, Cecilia C., Motta, Maria Cristina M., Sagot, Marie-France, Serrano, Myrna G., Teixeira, Marta M.G., Vasconcelos, Ana Tereza R.   +10 more
core   +5 more sources

CO2‐Dependent Promotion of Photosynthesis Drives Metabolic Photoacclimation in Chlamydomonas reinhardtii

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT Light and inorganic carbon (Ci) drive photosynthesis, which fuels cellular maintenance, energy storage, and growth in photosynthetic organisms. Despite its pivotal role, how primary metabolism adjusts to contrasting light and Ci availability in algae remains elusive.
Ana Pfleger, Erwann Arc, Thomas Roach
wiley   +1 more source

The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]

, 2018
Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul, Florencio Bellido, Francisco Javier, Klähn, Stephan, Muro Pastor, María Isabel   +3 more
core   +1 more source

Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Nucleotides are the building blocks of DNA and RNA. They also play essential roles in various other biological processes, including protein glycosylation, ribosome biogenesis, and cytoskeletal function. The significance of the regulation of nucleotide metabolism has recently gained more attention in many physiological and pathological contexts,
Lara Dsouza, Zhilong Yang
wiley   +1 more source

Valproate induces the unfolded protein response by increasing ceramide levels [PDF]

, 2016
Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects.
Cottier, Stéphanie, Cowart, Ashley, Greenberg, Miriam L., Jadhav, Shyamalagauri, Russo, Sarah, Schneiter, Roger   +5 more
core   +1 more source

Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies

Cancer, Volume 131, Issue 13, 1 July 2025.
This study uses comprehensive quantitative proteomics of 151 melanoma‐related samples to demonstrate that the upregulation of mitochondrial translation and oxidative phosphorylation is intricately linked to tumor aggressiveness, treatment resistance, and poor clinical outcomes.
Yonghyo Kim, Viktória Doma, Uğur Çakır, Magdalena Kuras, Lazaro Hiram Betancourt, Indira Pla, Aniel Sanchez, Yutaka Sugihara, Roger Appelqvist, Henriett Oskolas, Boram Lee, Jéssica Guedes, Gustavo Monnerat, Gabriel Reis Alves Carneiro, Fábio C. S. Nogueira, Gilberto B. Domont, Johan Malm, Bo Baldetorp, Elisabet Wieslander, István Balázs Németh, A. Marcell Szász, Runyu Hong, Krzysztof Pawłowski, Melinda Rezeli, Ho Jeong Kwon, Jozsef Timar, David Fenyö, Sarolta Kárpáti, György Marko‐Varga, Jeovanis Gil   +29 more
wiley   +1 more source