Transcriptome changes and cAMP oscillations in an archaeal cell cycle [PDF]
, 2007 Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Baumann, Anke +2 more
core +3 more sources
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System [PDF]
, 2016 Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity ...
Damm, Georg +11 more
core +2 more sources
Amino Acid Metabolism and Immune Dysfunction in Urea Cycle Disorders: T and B Cell Perspectives
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Urea cycle disorders (UCDs) are a group of genetic metabolic conditions characterized by enzyme deficiencies responsible for detoxifying ammonia. Hyperammonemia, the accumulation of intermediate metabolites, and a deficiency of essential amino acids—due to a protein‐restrictive diet and the use of ammonia scavengers—can increase the risk of ...
Betul Gemici Karaaslan +11 more
wiley +1 more source
Ammonia toxicity to the brain [PDF]
, 2018 Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood.
Braissant, Olivier +2 more
core
The effect of skin fatty acids on Staphylococcus aureus [PDF]
, 2014 Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production.
Albrecht, D. +8 more
core +3 more sources
, 2008 Gut microbial composition and activity exert a strong influence on the metabolic phenotype of the host, and variation in the metabolic phenotype is a major factor underlying inter-individual variation in drug responses.
Swann, Jonathan Richard +1 more
core
Convergence of Wnt signalling on the HNF4a-driven transcription in controlling liver zonation [PDF]
, 2009 BACKGROUND & AIMS: In each hepatocyte, the specific repertoire of gene expression is influenced by its exact location along the portocentrovenular axis of the hepatic lobule and provides a reason for the liver functions compartmentalization defined ...
Alonzi, T +7 more
core +1 more source
Metatranscriptome analyses indicate resource partitioning between diatoms in the field [PDF]
, 2014 Diverse communities of marine phytoplankton carry out half of global primary production. The vast diversity of the phytoplankton has long perplexed ecologists because these organisms coexist in an isotropic environment while competing for the same basic ...
Alexander, Harriet +3 more
core +2 more sources
Comparative biochemistry of CO2 fixation and the evolution of autotrophy [PDF]
, 2010 Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e.
Ana María Velasco +3 more
core +2 more sources
Comparative biochemistry of CO2 fixation and the evolution of autotrophy [PDF]
, 1999 Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e.
Becerra, Arturo +3 more
core