Results 81 to 90 of about 110,777 (250)

Complete genome of the multidrug-resistant Acinetobacter baumannii strain KBN10P02143 isolated from Korea

Memorias do Instituto Oswaldo Cruz, 2016
Acinetobacter baumannii, a strictly aerobic, non-fermentative, Gram-negative coccobacillary rod-shaped bacterium, is an opportunistic pathogen in humans. We recently isolated a multidrug-resistant A. baumannii strain KBN10P02143 from the pus sample drawn
Yong-Woon Lee, Hanna Choe, Sang-Heon Lee, Kyung Mo Kim, Sin Kam, Byung Kwon Kim, Won-Kil Lee   +6 more
doaj   +1 more source

1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family

European Journal of Organic Chemistry, EarlyView.
This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley   +1 more source

Distribution and Antimicrobial Resistance of Pathogenic Bacteria in Patients With Sternal Osteomyelitis

iLABMED, EarlyView.
This study conducted a retrospective analysis of microbiological culture results and antimicrobial resistance patterns in patients with sternal osteomyelitis at a tertiary medical center. The primary pathogens causing sternal osteomyelitis were gram‐positive bacteria. Infections with multidrug‐resistant organisms were also relatively common among these
Yumin Yang, Manhui Zhang, Yue Pan, Lihua Qi, Zhigang Wang, Xian Xia   +5 more
wiley   +1 more source

Application of Artificial Intelligence in Clinical Microbiology: From Research to Practice

iLABMED, EarlyView.
This paper reviews the application of AI in clinical microbiology practice at home and abroad, including rapid pathogen identification, accurate characterization of microbial resistance patterns, optimization of laboratory workflows, and public health interventions.
Ting Ding, Yi‐Wei Tang, Xiaoke Hao
wiley   +1 more source

Detection of blaNDM‐1 and blaIMP‐1 Metallo‐β‐Lactamases in Meropenem‐Resistant Clinical Escherichia coli Isolates Using Modified Carbapenem Inactivation Method (mCIM) and PCR Techniques

Journal of Clinical Laboratory Analysis, EarlyView.
This study examines the prevalence of blaNDM‐1 and blaIMP‐1 metallo‐β‐lactamase genes in meropenem‐resistant Escherichia coli isolates using mCIM and PCR. The results indicate a higher prevalence of blaNDM‐1 and suggest the presence of alternative resistance mechanisms in some strains, emphasizing the need for further research on antimicrobial ...
Mehdi Roshdi Maleki
wiley   +1 more source

Novel nanoparticle‐mediated plasmid delivery in bacteria for difficult applications

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study presents the development and application of magnetite/silver‐pDMAEMA‐PEG‐BUFII nanobioconjugates as an advanced plasmid delivery system in bacteria. These nanobioconjugates demonstrated superior efficiency compared to traditional methods in four challenging applications: (i) genomic editing in Gram‐positive bacteria; (ii)
Laura D. Páez‐Angarita, Laura X. Henao, Sebastián Jaramillo‐Toro, Valentina Quezada, Silvia Restrepo, Juan C. Cruz, Johana Husserl   +6 more
wiley   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living. The effectiveness of broad‐spectrum antibiotics in treating NHCAP remains unclear.
Jumpei Taniguchi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga   +4 more
wiley   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Discrepancies in Beta‐Lactam Antibiotics Cross‐Reactivity: Implications for Clinical Practice

Allergy, EarlyView.
Four studies previously published on beta‐lactam antibiotics cross‐reactivity were compared head‐to‐head. These studies covered 51 antibiotics, theoretically leading to 2550 potential recommendations regarding alternatives in case of specific allergies. The studies analysed different sets of beta‐lactam antibiotics.
Evelien Maria Hutten, Maja Bulatović Ćalasan, Jason Anthony Trubiano, Rick Gert‐Jan Pleijhuis, Ingrid Terreehorst   +4 more
wiley   +1 more source

Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]

, 2016
Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa, Barberis, Claudia, Cittadini, Roxana, Del Castillo M,, Lazzaro, T., Montaña, Sabrina Daiana, Ramírez, M. S., Uong, S., Vay, Carlos Alberto   +8 more
core   +1 more source