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The emerging NDM carbapenemases
Trends in Microbiology, 2011Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice +3 more
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Reviews in Medical Microbiology, 2017
Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali +4 more
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Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali +4 more
openaire +1 more source
European Journal of Clinical Microbiology & Infectious Diseases, 2022
Klebsiella pneumoniae carbapenemase (KPC)-2, metallo-beta-lactamases (MBL), and oxacillinase (OXA)-48-like carbapenemases are considered the most important carbapenemases. In vitro studies have demonstrated that the carbapenemase activity of KPC-2 and MBL can be inhibited by 3-aminophenylboronic acid and ethylenediaminetetraacetic acid (EDTA ...
Gen Li +8 more
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Klebsiella pneumoniae carbapenemase (KPC)-2, metallo-beta-lactamases (MBL), and oxacillinase (OXA)-48-like carbapenemases are considered the most important carbapenemases. In vitro studies have demonstrated that the carbapenemase activity of KPC-2 and MBL can be inhibited by 3-aminophenylboronic acid and ethylenediaminetetraacetic acid (EDTA ...
Gen Li +8 more
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Detection systems for carbapenemase gene identification should include the SME serine carbapenemase
International Journal of Antimicrobial Agents, 2013Carbapenemase detection has become a major problem in hospitals that encounter outbreaks of infections caused by carbapenem-resistant Gram-negative bacteria. Rapid detection systems have been reported using multiplex PCR analyses and DNA microarray assays.
Karen, Bush +7 more
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