Results 181 to 190 of about 52,626 (218)
Some of the next articles are maybe not open access.
Journal of Chemotherapy, 2013
To assess the relative strengths and weaknesses of carbapenems by considering their microbiological, clinical, pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) properties and defining optimal conditions of uses of the new generation of carbapenems.Literature review.Except for ertapenem, the spectrum of activity is similar for all ...
Dominique, Breilh +4 more
openaire +2 more sources
To assess the relative strengths and weaknesses of carbapenems by considering their microbiological, clinical, pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) properties and defining optimal conditions of uses of the new generation of carbapenems.Literature review.Except for ertapenem, the spectrum of activity is similar for all ...
Dominique, Breilh +4 more
openaire +2 more sources
Medical Clinics of North America, 1995
Carbapenems are broad-spectrum beta-lactam antibiotics that cover an absolute majority of all bacterial pathogens that possess a cell wall. The only clinically important exceptions are X. maltophilia, E. faecium, and some strains of methicillin-resistant staphylococci and penicillin-resistant pneumococci.
openaire +2 more sources
Carbapenems are broad-spectrum beta-lactam antibiotics that cover an absolute majority of all bacterial pathogens that possess a cell wall. The only clinically important exceptions are X. maltophilia, E. faecium, and some strains of methicillin-resistant staphylococci and penicillin-resistant pneumococci.
openaire +2 more sources
Therapeutic Drug Monitoring, 2003
Antimicrobial resistance is increasing among bacterial pathogens. In particular, organisms producing extended spectrum beta-lactamase enzymes (ESBLs) and AmpC chromosomal beta-lactamase enzymes are resistant to third generation cephalosporins and pose a formidable challenge in the management of seriously ill patients.
Kassa, Ayalew +3 more
openaire +2 more sources
Antimicrobial resistance is increasing among bacterial pathogens. In particular, organisms producing extended spectrum beta-lactamase enzymes (ESBLs) and AmpC chromosomal beta-lactamase enzymes are resistant to third generation cephalosporins and pose a formidable challenge in the management of seriously ill patients.
Kassa, Ayalew +3 more
openaire +2 more sources
Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams
Journal of Medicinal Chemistry, 1990The photo "Wolff" rearrangement of readily available 2-diazoceph-3-em oxides (1) directly affords carbapen-2-ems, allowing a facile entry into a ring system previously accessible only by total synthesis, lengthly semisynthesis or fermentation. The chirality of the cephalosporin is accurately translated into the corresponding carbapenem. The resulting 1-
R L, Rosati +3 more
openaire +2 more sources
Obstetrics and Gynecology Clinics of North America, 1989
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
openaire +2 more sources
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
openaire +2 more sources
Recent developments in carbapenems
Expert Opinion on Investigational Drugs, 2002Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin.
Giovanni, Bonfiglio +2 more
openaire +2 more sources