Results 161 to 170 of about 39,994 (209)
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Therapeutic Drug Monitoring, 2003
Antimicrobial resistance is increasing among bacterial pathogens. In particular, organisms producing extended spectrum beta-lactamase enzymes (ESBLs) and AmpC chromosomal beta-lactamase enzymes are resistant to third generation cephalosporins and pose a formidable challenge in the management of seriously ill patients.
Kassa, Ayalew +3 more
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Antimicrobial resistance is increasing among bacterial pathogens. In particular, organisms producing extended spectrum beta-lactamase enzymes (ESBLs) and AmpC chromosomal beta-lactamase enzymes are resistant to third generation cephalosporins and pose a formidable challenge in the management of seriously ill patients.
Kassa, Ayalew +3 more
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Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams
Journal of Medicinal Chemistry, 1990The photo "Wolff" rearrangement of readily available 2-diazoceph-3-em oxides (1) directly affords carbapen-2-ems, allowing a facile entry into a ring system previously accessible only by total synthesis, lengthly semisynthesis or fermentation. The chirality of the cephalosporin is accurately translated into the corresponding carbapenem. The resulting 1-
R L, Rosati +3 more
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Medical Clinics of North America, 1995
Carbapenems are broad-spectrum beta-lactam antibiotics that cover an absolute majority of all bacterial pathogens that possess a cell wall. The only clinically important exceptions are X. maltophilia, E. faecium, and some strains of methicillin-resistant staphylococci and penicillin-resistant pneumococci.
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Carbapenems are broad-spectrum beta-lactam antibiotics that cover an absolute majority of all bacterial pathogens that possess a cell wall. The only clinically important exceptions are X. maltophilia, E. faecium, and some strains of methicillin-resistant staphylococci and penicillin-resistant pneumococci.
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Obstetrics and Gynecology Clinics of North America, 1989
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Recent developments in carbapenems
Expert Opinion on Investigational Drugs, 2002Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin.
Giovanni, Bonfiglio +2 more
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Journal of Infection and Chemotherapy, 2018
The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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Comparative Review of the Carbapenems
Drugs, 2007The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to the class such as
George G, Zhanel +7 more
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CEPHALOSPORINS, CARBAPENEMS, AND MONOBACTAMS
Infectious Disease Clinics of North America, 2000Nonpenicillin beta-lactams exhibit a variable spectrum of antimicrobial activity, have a wide range of clinical uses and a favorable safety profile. Cefepime's twice-daily dosage and increased activity against Enterobacteriaceae may offer some advantages over older cephalosporins.
L E, Asbel, M E, Levison
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Neurotoxicity of Carbapenem Antibacterials
Drug Safety, 1996Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
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Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems
European Journal of Medicinal Chemistry, 2005Syntheses of racemic trans-3-hydroxycarbonyl-6-(phenylacetamido)carbapenem (13), trans-3-phosphono-6-(phenylacetamido)carbapenem (17), and beta-lactam based prodrugs 19 and 22 were accomplished. Carbapenem 13 was found to possess antibacterial activity, comparable with imipenem (+)-3, against Staphylococcus aureus FDA 209P, S.
Gholam Hossein, Hakimelahi +5 more
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