Results 211 to 220 of about 52,330 (263)

Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins

Allergy: European Journal of Allergy and Clinical Immunology, 2013
Studies performed on subjects with IgE-mediated hypersensitivity to penicillins have demonstrated a 1% rate of cross-reactivity between penicillins and both imipenem and meropenem, while a single study found a 5.5% rate of cross-reactivity with imipenem ...
Cristiano Caruso, Rocco Luigi Valluzzi
exaly   +2 more sources

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Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams

Journal of Medicinal Chemistry, 1990
The photo "Wolff" rearrangement of readily available 2-diazoceph-3-em oxides (1) directly affords carbapen-2-ems, allowing a facile entry into a ring system previously accessible only by total synthesis, lengthly semisynthesis or fermentation. The chirality of the cephalosporin is accurately translated into the corresponding carbapenem. The resulting 1-
R L, Rosati, L V, Kapili, P, Morrissey, J A, Retsema   +3 more
openaire   +2 more sources

Clinical pharmacology of carbapenems in neonates

Journal of Chemotherapy, 2014
Carbapenems are an effective tool to treat complicated bacterial infections. This review aims to summarize the available information on carbapenems in neonates to guide clinicians on drug choice and indications in neonates.
Karel Allegaert, Gian Maria Pacifici
exaly   +2 more sources

Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems? [PDF]

Clinical Microbiology and Infection, 2011
Infections caused by carbapenemase-producing Klebsiella pneumoniae (CPKP) are increasing in frequency worldwide. CPKP isolates exhibit extensive drug resistance phenotypes, complicate therapy, and limit treatment options. Although CPKP isolates are often
G L Daikos
exaly   +2 more sources

Carbapenems

Medical Clinics of North America, 1995
Carbapenems are broad-spectrum beta-lactam antibiotics that cover an absolute majority of all bacterial pathogens that possess a cell wall. The only clinically important exceptions are X. maltophilia, E. faecium, and some strains of methicillin-resistant staphylococci and penicillin-resistant pneumococci.
openaire   +2 more sources

Carbapenems as Antidotes for the Management of Acute Valproic Acid Poisoning

Pharmaceuticals
Introduction: Valproic acid (VPA) is a broad-spectrum drug primarily used in the treatment of epilepsy and bipolar disorder. It is not an uncommon occurrence for VPA to cause intoxication.
Dejan Zivanovic, Vesna Mijatović Jovin, Marko Antunovic   +2 more
exaly   +2 more sources

Carbapenems and Penems

Obstetrics and Gynecology Clinics of North America, 1989
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Comparative Review of the Carbapenems

Drugs, 2007
The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to the class such as
George G, Zhanel, Ryan, Wiebe, Leanne, Dilay, Kristjan, Thomson, Ethan, Rubinstein, Daryl J, Hoban, Ayman M, Noreddin, James A, Karlowsky   +7 more
openaire   +2 more sources

A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa

Journal of Infection and Chemotherapy, 2018
The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama, Kumiko Yasui, Hinako Murakami, Takayoshi Kosugi, Maki Sakamoto, Yuki Hanai, Kazuhiro Matsuo, Taito Miyazaki, Yoshikazu Ishii, Kenji Nishizawa, Kazuhiro Tateda   +10 more
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Recent developments in carbapenems

Expert Opinion on Investigational Drugs, 2002
Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin.
Giovanni, Bonfiglio, Giovanni, Russo, Giuseppe, Nicoletti   +2 more
openaire   +2 more sources