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CEPHALOSPORINS, CARBAPENEMS, AND MONOBACTAMS

Infectious Disease Clinics of North America, 2000
Nonpenicillin beta-lactams exhibit a variable spectrum of antimicrobial activity, have a wide range of clinical uses and a favorable safety profile. Cefepime's twice-daily dosage and increased activity against Enterobacteriaceae may offer some advantages over older cephalosporins.
L E, Asbel, M E, Levison
openaire   +2 more sources

Ertapenem: a new carbapenem

Expert Opinion on Investigational Drugs, 2001
Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
openaire   +2 more sources

Neurotoxicity of Carbapenem Antibacterials

Drug Safety, 1996
Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
openaire   +2 more sources

Carbapenems for Surgical Prophylaxis?

New England Journal of Medicine, 2006
In this issue of the Journal, Itani and colleagues1 describe a study in which 1002 patients were randomly assigned to receive either ertapenem or cefotetan in a single dose before elective colorectal surgery. Many experienced surgeons and hospital epidemiologists will probably be surprised that the overall rate of failure in the modified intention-to ...
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Bacterial Resistance to Carbapenems

1995
The carbapenems have the broadest spectra of all beta-lactams but resistance still occurs, caused by target modification, impermeability or beta-lactamase production. Target modification or replacement is important in methicillin-resistant staphylococci, E. faecium and some pneumococci.
openaire   +2 more sources

Carbapenems

Seminars in Pediatric Infectious Diseases, 2001
Katherine M. Knapp, B.Keith English
openaire   +1 more source

Long-Term Carbapenems Antimicrobial Stewardship Program

Antibiotics, 2021
José Francisco García-Rodríguez
exaly  

Carbapeneme

2005
Manfred Fille   +3 more
openaire   +1 more source

Ertapenem, the first of a new group of carbapenems

Journal of Antimicrobial Chemotherapy, 2003
Pramod M Shāh
exaly  

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