Results 141 to 150 of about 6,109 (244)

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, EarlyView.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Background The aryl hydrocarbon receptor (AhR) is linked to inflammation, but its plasma agonist activity and association with metabolic and inflammatory markers in obesity remain unclear. This cross‐sectional study aimed to determine the level of plasma AhR agonistic activity and its association with systemic inflammation and metabolic ...
Fatemah Bahman, Shihab Kochumon, Ashraf Al Madhoun, Areej Al‐Roub, Abdullah Bennakhi, Monira Arouj, Fahd Al‐Mulla, Rasheed Ahmad   +7 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity. [PDF]

Molecules, 2018
Saturnino C, Grande F, Aquaro S, Caruso A, Iacopetta D, Bonomo MG, Longo P, Schols D, Sinicropi MS.   +8 more
europepmc   +1 more source

The role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury

British Journal of Pharmacology, Volume 183, Issue 13, Page 3815-3828, July 2026.
Abstract Background and Purpose Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.
Ilter Ilhan, Halil Aşcı, Muhammet Yusuf Tepebasi, Nursel Hasseyid, Melih Arlıoğlu, Özlem Özmen   +5 more
wiley   +1 more source

Visible Light‐Induced Transformation of β‐Aryl‐α,β‐Unsaturated Acylsilanes into Indenol Derivatives via Alkenyl Siloxycarbenes

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Visible light activates β‐aryl α,β‐unsaturated acylsilanes to form indenols without catalysts or metals. A stepwise photochemical cascade reorganizes simple precursors through isomerization, rearrangement, and ring formation. The process highlights sustainable reaction design while showcasing the synthetic power of acylsilane photochemistry and the ...
Adrián Álvarez, Iván Rivilla, Fernando P. Cossío, Manuel Plaza, Félix Rodríguez   +4 more
wiley   +1 more source

Synthesis of Aromatic Aldehydes by CH Formylation of Aromatics with Silyl Formates Prepared from CO2 and Hydrosilanes

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
A new method has been developed for the C–H formylation of aromatic compounds using silyl formates synthesized from CO2 and hydrosilanes. This is the first report on the direct C–H formylation of aromatics with silyl formates. The formylation reactions were promoted by BBr3 or BCl3. The reaction mechanism has been clarified by DFT calculations. Despite
Natsumi Nitta, Kei Hirokawa, So Saibara, Bikash Dev Nath, Kazuto Takaishi, Tadashi Ema   +5 more
wiley   +1 more source

Luminescent Donor‐Acceptor Radical With Propeller Chirality: Bright and Photostable Red Circularly Polarized Luminescence and Whispering Gallery Mode Resonance

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
A series of donor‐attached brominated chiral luminescent radicals (CzTTBrM, 2CzTTBrM, and 3CzTTBrM) was synthesized, showing red to near‐infrared (NIR) circularly polarized luminescence (CPL) with exceptionally high PLQY of up to 76% and markedly enhanced CPL brightness (BCPL). Doping into polystyrene microspheres further yields whispering gallery mode
Kazuhiro Nakamura, Kenshiro Matsuda, Kosuke Anraku, Keiko Yamaoka, Taisuke Matsumoto, Fumitaka Ishiwari, Takeaki Zaima, Wataru Ota, Emiko Fujiwara, Tohru Sato, Yoshitaka Inoue, Soh Kushida, Yohei Yamamoto, Takuya Hosokai, Ken Albrecht   +14 more
wiley   +2 more sources

Synthesis of β‐Enamino Sulfoxides via Cine‐Substitution of 1‐Chlorovinyl p‐Tolyl Sulfoxides with Lithium Amides

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
The cine‐substitution of 2‐aryl‐1‐chlorovinyl p‐tolyl sulfoxides with lithium amides yields β‐enamino sulfoxides with high efficiency. β‐Enamino sulfoxides are desulfinylated via the sulfoxide/magnesium exchange reaction with isopropylmagnesium chloride to yield enamines.
Tsutomu Kimura, Rio Dohira, Masataka Ogasawara, Takahiro Tsuru, Tsuyoshi Satoh   +4 more
wiley   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source