Results 141 to 150 of about 6,142 (231)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment. [PDF]

Sci Rep, 2017
Bachurin SO, Shevtsova EF, Makhaeva GF, Grigoriev VV, Boltneva NP, Kovaleva NV, Lushchekina SV, Shevtsov PN, Neganova ME, Redkozubova OM, Bovina EV, Gabrelyan AV, Fisenko VP, Sokolov VB, Aksinenko AY, Echeverria V, Barreto GE, Aliev G.   +17 more
europepmc   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Excited‐State Antiaromaticity in Nonbenzenoid Aromatics: Examining the Dynamics of Intramolecular Proton Transfer With a Small Driving Force

Angewandte Chemie, Volume 138, Issue 33, 10 August 2026.
The excited‐state antiaromaticity of hydroxybenzotropyliums (HBTs) can be tuned through substituent effects to bring the aromatic ‘enol’ (E) and keto (K) tautomers close in energy. This leads to abnormally slow excited‐state proton transfer (on the ns timescale), giving rise to dual fluorescence emission and weak photoacidity.
Promeet K. Saha, Charlotte A. Bardsley, Hector G. Miranda‐Salinas, Daniel Crane, Rabia Ayub, Andrew P. Monkman, Paul R. McGonigal   +6 more
wiley   +2 more sources

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

Alcohol exposure promotes cell communication network 1 cleavage in esophageal adenocarcinoma cells exclusively

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
An illustration shows how cell communication network 1 (CCN1) is involved in the normal esophagus, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EAC) after alcohol exposure. Alcohol exposure upregulates CCN1 expression in the esophageal epithelium, with or without esophageal cancer. In normal individuals, CCN1 repairs tissue
Wula Aladan, Baoxin Chi, Zhiheng Chang, Mizhu Wang, Tong Dang, Xianmei Meng, Jianyuan Chai   +6 more
wiley   +1 more source

Design and Photophysical Investigation of Schiff Base-Functionalized Pyrrolo[3,2-c]carbazoles. [PDF]

J Fluoresc
Özbek G, Kaya EN, Saglam MF, Kandemir H, Sengul IF.   +4 more
europepmc   +1 more source

Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2019
Chen H, Qiao C, Miao TT, Li AL, Wang WY, Gu W.   +5 more
europepmc   +1 more source

Solvent Polarity as a Selective Modulator of the First Hyperpolarizability in Para-Substituted Azo-Carbazole Dyes. [PDF]

ACS Omega
Ferreira MBM, Georg HC, Castro MA, Fonseca TL.   +3 more
europepmc   +1 more source