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Antioxidant activity of carbocysteine lysine salt monohydrate.
Panminerva medica, 2001 Reactive oxygen radicals are involved in many respiratory diseases, including chronic obstructive pulmonary disease (COPD). Carbocysteine lysine salt monohydrate (CLS) is a mucoactive drug effective in the treatment of bronchopulmonary diseases characterized by mucus alterations, including COPD. In the present study, the antioxidant activity of CLS was
PINAMONTI, Silvano +9 more
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Relative Bioavailability of Carbocysteine From Three Dosage Forms Investigated in Healthy Volunteers
Biopharmaceutics and Drug Disposition, 1988AbstractThe aim of the present study was to evaluate the bioavailability of a new tablet formulation of carbocysteine relative against two other oral carbocysteine containing dosage forms, viz. a syrup and capsules. Plasma levels and urine concentrations of carbocysteine were monitored, following oral administration of all three dosage forms to healthy
exaly +3 more sources
Efficacy of carbocysteine in acute exacerbation of chronic obstructive pulmonary disease
Russian Pulmonology, 2012 Summary. This study was designed to evaluate clinical efficacy and safety of carbocysteine lysine salt in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).
S. N. Avdeev +2 more
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Topical carbocysteine: A new option for the treatment of ichthyosis
Pediatric Dermatology, 2018AbstractN‐acetylcysteine in combination with urea is effective for the treatment of congenital ichthyosis. Although it is well tolerated, its foul smell may compromise treatment adherence. Carbocysteine is a similar molecule without that bad odor. Thus, we have tried a new formula with carbocysteine for the treatment of 4 patients with ichthyosis, with
Ana Batalla +3 more
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International Journal of Pharmaceutics, 1991 A kinetic-potentiometric method is described for the determination of carbocysteine in coloured pharmaceutical preparations based on monitoring its reaction with 1-fluoro-2,4-dinitrobenzene, catalysed by cetyltrimethylammonium bromide micelles, using a ...
C E Efstathiou
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Investigational Drug Information; Carbocysteine
Drug Intelligence & Clinical Pharmacy, 1988Carbocysteine is prescribed for conditions characterized by the accumulation of excessive mucus. Although often described as a mucolytic, its function is probably that of mucoregulation, which results in physical changes in accumulated secretions that are favorable in terms of clearance.
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Evaluation of proposed sulphoxidation pathways of carbocysteine in man by HPLC quantification
European Journal of Clinical Pharmacology, 1991A quantitative study has been made of the metabolism of S-carboxymethyl-L-cysteine (CMC) and its sulphoxides in volunteers by HPLC. Precolumn derivatization was applied prior to gradient reversed phase HPLC separation and fluorescence detection. For CMC and its metabolites containing a primary amino group the reagent 9-fluorenylmethylchloroformate was ...
J, Brockmöller, B, Staffeldt, I, Roots
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[Carbocysteine in catarrhal ORL diseases].
Revue de laryngologie - otologie - rhinologie, 1991By stimulating an enzyme, the sialyltransferase, Carbocisteine has a privileged place in mucomodifying therapeutics. It allows the substitution of pathologic secretions, congesting and aggressive, by physiologic restructured mucus. Tested with success in the E.N.T.
J P, Bébéar +2 more
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[Carbocysteine in the treatment of recurrent bronchitis in infants].
Ceskoslovenska pediatrie, 1992In a group of 51 children aged 6-24 months the therapeutic effectiveness of the mucolytic preparation carbocysteine was tested and compared with the effect of Ipeca syrup. The effect was evaluated by means of a point score comprising changes of the clinical picture of the disease and the use of other laboratory examinations.
P, Bánovcin +4 more
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Biochemical Pharmacology, 1991
Abstract The metabolism of the mucolytic agent carbocysteine ( S- carboxymethyl- l -cysteine , CMC) has attracted substantial interest during recent years [1]. It has been reported that sulphoxidation of CMC and its cysteinyl metabolites consitutes a major pathway of biotransformation.
C O, Meese +4 more
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Abstract The metabolism of the mucolytic agent carbocysteine ( S- carboxymethyl- l -cysteine , CMC) has attracted substantial interest during recent years [1]. It has been reported that sulphoxidation of CMC and its cysteinyl metabolites consitutes a major pathway of biotransformation.
C O, Meese +4 more
openaire +2 more sources