Results 51 to 60 of about 1,615,052 (245)

Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.

PLoS ONE, 2014
We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C ...
Keiko Handa, Kouichi Inukai, Hirohisa Onuma, Akihiko Kudo, Fumiyuki Nakagawa, Kazue Tsugawa, Atsuko Kitahara, Rie Moriya, Kazuto Takahashi, Yoshikazu Sumitani, Toshio Hosaka, Hayato Kawakami, Seiichi Oyadomari, Hitoshi Ishida   +13 more
doaj   +1 more source

Carbohydrate Restriction Alters Hepatic Cholesterol Metabolism in Guinea Pigs Fed a Hypercholesterolemic Diet [PDF]

The Journal of Nutrition, 2007
The current study was undertaken to evaluate the effect of carbohydrate restriction on hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet. Hartley male guinea pigs (n = 10 per group) were fed 1 of 3 diets: a diet with a percent energy distribution of 42:23:35 carbohydrate:protein:fat and 0.04% cholesterol (control), a diet ...
Torres-Gonzalez, M, Shrestha, S, Sharman, Matthew, Freake, H, Volek, J, Fernandez, M   +5 more
openaire   +3 more sources

The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial

BMC Medicine, 2023
Background Both low‐carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared.
Jia Sun, Yuting Ruan, Ningning Xu, Peili Wu, Nie Lin, Kun Yuan, Shengli An, Pei Kang, Shu Li, Qiya Huang, Yingzhang, Yuzhong Li, Jialin Su, Wenjun Ma, Bo Chen, Xiuwei Zhang, Xiaoming Chen, Yongqian Liang, Zeyuan Lu, Guobao Deng, Zhen Zhang, Yuqin Wang, Weiheng Wen, Huijie Zhang, Hong Chen   +24 more
doaj   +1 more source

The effects of a three-week restricted carbohydrate diet on exercise metabolism and performance of three cyclists

, 2018
Introduction Restricted carbohydrate diets (RCDs) have become popular amongst endurance athletes as a means of increasing fat oxidation and improving health outcomes. However, it is unclear if these adaptations improve exercise performance.
Hough, P.
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring [PDF]

, 2009
Background :miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known whether a maternal high fat (HF) diet during pregnancy
Zhang F, Bruce, KD, Zhang J, Didelot, Xavier, Didelot Xavier, Lehnert Hendrik, Zhang, F. (Fang), Ceriello Antonio, Lehnert, Hedrik, Zhang, Fang, Vatish M, Didelot X, Hanson Mark, Byrne, CD, Cagampang, Felino R., Ceriello, Antonio, Vatish, Manu, Byrne, Christopher D., Zhang Junlong, Byrne Christopher D, Didelot, X, Bruce Kimberley D, Hanson M, Ceriello, A, Lehnert, H, Hanson, Mark, Zhang, Junlong, Cagampang Felino R, Zhang Fang, Bruce KD, Zhang, F, Cagampang FR, Cagampang, FR, Byrne C.D., Hanson, M, Vatish Manu, Vatish, M, Hanson, Mark A., Lehnert H, Bruce, Kimberley D., Lehnert, Hendrik, Zhang, J   +41 more
core   +1 more source

Soft Hypoxia‐Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed‐Loop Therapeutics of Chronic Wounds

Advanced Science, EarlyView.
Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao, Gang Song, Pingqiang Cai, Zheng Li, Zhiyuan Liu, Dianpeng Qi, Ting Wang, Lianhui Wang   +16 more
wiley   +1 more source

Low-carbohydrate diets differing in carbohydrate restriction improve cardiometabolic and anthropometric markers in healthy adults: A randomised clinical trial [PDF]

PeerJ, 2019
Background Low-carbohydrate, high-fat (LCHF) diets are useful for treating a range of health conditions, but there is little research evaluating the degree of carbohydrate restriction on outcome measures.
Cliff J. d. C. Harvey, Grant M. Schofield, Caryn Zinn, Simon J. Thornley, Catherine Crofts, Fabrice L. R. Merien   +5 more
doaj   +2 more sources

Carbohydrate restriction in the larval diet causes oxidative stress in adult insects of Drosophila melanogaster [PDF]

The Ukrainian Biochemical Journal, 2013
The influence of 20 and 1% glucose and fructose, which were components of larval diet, on the level of oxidized proteins and lipids, low molecular mass antioxidant content as well as activities of antioxidant and associated enzymes in adult fruit fly Drosophila melanogaster were investigated.
B M, Rovenko, V I, Lushchak, O V, Lushchak   +2 more
openaire   +2 more sources

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source