Results 221 to 230 of about 876,956 (399)

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

Does agroecosystem management mitigate historic climate impacts on dryland winter wheat yields?

open access: yesAgronomy Journal, Volume 114, Issue 6, Page 3515-3530, November/December 2022., 2022
Abstract Global studies that quantify climate effects on crop yields using top‐down spatial frameworks are invaluable for assessing generalized effects on world food supplies, yet do not contain the resolution necessary to identify local mediating effects of management. Our objectives were to identify (a) what climate factors have historically affected
Grace L. Miner   +6 more
wiley   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen   +16 more
wiley   +1 more source

Profit‐maximizing potassium fertilizer recommendations for corn and cotton

open access: yesAgronomy Journal, Volume 114, Issue 6, Page 3358-3376, November/December 2022., 2022
Abstract Whereas K fertilization is necessary to maximize corn (Zea mays L.) and cotton (Gossypium hirsutum L.) yields in soils with sub‐optimum K availability, maximizing yield is rarely profit‐maximizing. Estimating the tradeoff between yield and fertilizer cost using current soil‐building and/or yield‐maximizing rate recommendations vs.
Kimberly Oliver   +4 more
wiley   +1 more source

Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA

open access: yesAdvanced Science, EarlyView.
In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa   +5 more
wiley   +1 more source

Structural and functional insights into metal coordination and substrate recognition of Akkermansia muciniphila sialidase Amuc_1547. [PDF]

open access: yesMol Biomed
Li T   +14 more
europepmc   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

open access: yesAdvanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang   +3 more
wiley   +1 more source

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