Results 261 to 270 of about 113,600 (307)

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Novel compound heterozygous mutations in LMAN2L cause early childhood refractory epilepsy. [PDF]

Ital J Pediatr
Wang T, Gao Y, Yan Y, Yin P, Tong L, Dong M.   +5 more
europepmc   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

Polarizable AMOEBA force field predicts thin and dense hydration layer around monosaccharides.

Chem Commun (Camb)
Newman LA, Patton MG, Rodriguez BA, Sumner EW, Vaissier Welborn V.   +4 more
europepmc   +1 more source

Synergetic Effect of β-Cyclodextrin and Its Simple Carbohydrate Substituents on Complexation of Folic Acid and Its Structural Analog Methotrexate. [PDF]

Pharmaceutics
Ceborska M, Siklitskaya A, Kowalska AA, Kędra K.   +3 more
europepmc   +1 more source

Engineering Yarrowia lipolytica to Enhance the Production of Malonic Acid via Malonyl‐CoA Pathway at High Titer

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The non‐conventional oleaginous yeast Y. lipolytica has been genetically engineered to produce malonic acid via malonyl‐CoA pathway through introducing an efficient malonyl‐CoA hydrolase. Advanced metabolic engineering and optimization of fermentation conditions resulted in a malonic acid production yield of 19.1 g L−1 in shaking‐flasks.
Qun Yang, Mengzhen Tian, Ping Dong, Yunying Zhao, Yu Deng   +4 more
wiley   +1 more source

Host-Guest Dynamic Behavior of Melatonin Encapsulated in β-Cyclodextrin Nanosponges. [PDF]

ACS Omega
Ferrero R, Pantaleone S, Brunella V, Corno M, Jiménez-Osés G, Peccati F.   +5 more
europepmc   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, Volume 12, Issue 19, May 22, 2025.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Structure-Based Mechanism and Specificity of Human Galactosyltransferase β3GalT5. [PDF]

J Am Chem Soc
Lo JM, Kung CC, Cheng TR, Wong CH, Ma C.
europepmc   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source