Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]
, 2015 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus +9 more
core +5 more sources
Crystal structure of [(2R,3R,4S)-3,4-bis(acetyloxy)-5-iodo-3,4-dihydro-2H-pyran-2-yl]methyl acetate
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C12H15IO7, the 3,4-dihydro-2H-pyran ring is in a distorted half-boat conformation with the atom bearing the acetyloxy group adjacent to the C atom bearing the methylacetate group lying 0.633 (6) Å above the plane of the remaining ...
Julio Zukerman-Schpector +4 more
doaj +1 more source
A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]
, 2015 Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K +5 more
core +1 more source
Journal of Molecular Biology, 1996 The structure of the complex of the tetrameric peanut lectin with lactose has been refined to an R-value of 16.4% using 2.25 angstroms resolution X-ray diffraction data. The subunit conformation in the structure is similar to that in other legume lectins
Rahul Banerjee +5 more
semanticscholar +1 more source
An Introduction to Biomolecular Simulations and Docking [PDF]
, 2014 The biomolecules in and around a living cell -- proteins, nucleic acids, lipids, carbohydrates -- continuously sample myriad conformational states that are thermally accessible at physiological temperatures. Simultaneously, a given biomolecule also samples (and is sampled by) a rapidly fluctuating local environment comprised of other biopolymers, small
arxiv +1 more source
Carbohydrate NMR chemical shift predictions using E(3) equivariant graph neural networks [PDF]
arXiv, 2023 Carbohydrates, vital components of biological systems, are well-known for their structural diversity. Nuclear Magnetic Resonance (NMR) spectroscopy plays a crucial role in understanding their intricate molecular arrangements and is essential in assessing and verifying the molecular structure of organic molecules. An important part of this process is to
arxiv
Nanostructure of cellulose microfibrils in spruce wood [PDF]
, 2011 The structure of cellulose microfibrils in wood is not known in detail, despite the abundance of cellulose in woody biomass and its importance for biology, energy, and engineering.
A. N. Fernandes +34 more
core +2 more sources
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Das Kupfertetramminion, ein empfindliches Reagens für CD-Untersuchungen von Kohlenhydraten
CHIMIA, 1973 The circular dichroism spectra of carbohydrate copper tetrammonia solutions allow to get valuable information about the configuration and conformation of sugars.
Wolfgang Voelter +2 more
doaj +1 more source
Carbohydrate moieties of major histocompatibility complex class I alloantigens are not required for their recognition by T lymphocytes. [PDF]
, 1985 The ability to generate specific cytotoxic responses using purified major histocompatibility complex (MHC) antigen in liposomes has made it possible to directly assess the importance of class I carbohydrate moieties in T cell recognition of alloantigen ...
Goldstein, SA, Mescher, MF
core