Results 11 to 20 of about 2,048 (147)

Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase [PDF]

Comput Struct Biotechnol J
UDP-galactose 4-epimerases (Gal4Es) catalyze the inversion of the 4-hydroxyl configuration of a sugar moiety from an NDP-sugar through a three-step process: oxidation, rotation and reduction. Despite extensive biochemical and structural studies, the role
Alvarez Quispe, Carlos Josué, Beerens, Koen, Biarnés, Xevi, Desmet, Tom, Planas, Antoni, Thunnissen, Andy Mark W.H.   +5 more
core   +2 more sources

Diversity and function of phage encoded depolymerases [PDF]

, 2020
Bacteriophages of the Podoviridae family often exhibit so-called depolymerases as structural components of the virion. These enzymes appear as tail spike proteins (TSPs).
Fieseler, Lars, Knecht, Leandra E., Veljkovic, Marjan   +2 more
core   +1 more source

Detecting Elusive Intermediates in Carbohydrate Conversion: A Dynamic Ensemble of Acyclic Glucose-Catalyst Complexes [PDF]

, 2017
The role of acyclic carbohydrates in pathways towards value-added chemicals has remained poorly characterized due to the low population of acyclic forms, and due to their instability under reaction conditions. We conduct steady-state and pre-steady state
Meier, Sebastian, Karlsson, Magnus, Jensen, Pernille Rose   +2 more
core   +1 more source

Structural Insights into the Epimerization of β-1,4-Linked Oligosaccharides Catalyzed by Cellobiose 2-Epimerase, the Sole Enzyme Epimerizing Non-anomeric Hydroxyl Groups of Unmodified Sugars [PDF]

, 2013
Cellobiose 2-epimerase (CE) reversibly converts d-glucose residues into d-mannose residues at the reducing end of unmodified β1,4-linked oligosaccharides, including β-1,4-mannobiose, cellobiose, and lactose.
Fujiwara, Takaaki, Matsui, Hirokazu, Mori, Haruhide, Saburi, Wataru, Yao, Min   +4 more
core   +1 more source

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation [PDF]

, 2020
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and ...
A Ghafoor, A Morin, AB Boraston, AW Blake, C Bundalovic-Torma, C Guerrero, C Ryder, C Steentoft, C Vuong, CM Payne, Collaborative Computational Project Number 4., CS Cummins, DC Sheppard, DE Blair, DE Blair, DJ Little, DJ Little, DJ Little, E Andrés, E Potterton, EN Kitova, F Le Mauff, F Sievers, FN Gravelat, FN Gravelat, GB Whitfield, GD Brown, GM Sheldrick, GM Sheldrick, H Aragunde, H Ashkenazy, H Ostapska, H Takada, H Zakariassen, J Hoßbach, J Sun, JA Jorge, JA Jorge, JJ Distler, JJ Tesmer, JL Reissig, JW Jensen, K Miyazawa, K Mizutani, KM Colvin, LA Kelley, LK Jennings, LS Marmont, M Gonzalez, M Oda, M Strong, MD Winn, MJ Lee, MJ Lee, MM Shaik, N Nwe, NA Baker, NC Bamford, NC Bamford, P Emsley, P Ruperez, P Vasseur, PC Bardalaye, PD Adams, PD Adams, RC Edgar, RE Lewis, S Jana, S Kaur, S Kumar, SC Potter, SF Altschul, T Fontaine, T Inoue, V Pokrovskaya, VE Fadouloglou, VK Köseoğlu, W Vollmer, W Wang, X Wang, X-L Li, Y Araki, Y Itoh, Y Kidani, Y Kidani   +84 more
core   +3 more sources

Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion [PDF]

, 2021
Epimerization of sugar nucleotides is central to the structural diversification of monosaccharide building blocks for cellular biosynthesis. Epimerase applicability to carbohydrate synthesis can be limited, however, by the high degree of substrate ...
Beerens, Koen, Desmet, Tom, Nidetzky, Bernd, Rapp, Christian, Van Overtveldt, Stevie, Weber, Hansjörg   +5 more
core   +2 more sources

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
Aimanianda, Aimanianda, Al-Fattani, Albrecht, Albuquerque, Alvarez, Arroyo, Babady, Baker, Beauvais, Beauvais, Beauvais, Becker, Bonhomme, Bowen, Brown, Bruno, Bulmer, Butler, Cabib, Cabib, Cabib, Cabib, Casadevall, Casadevall, Cassone, Cassone, Castillo, Chaffin, Cheetham, Cho, Coronado, Couto, Crowe, Cushion, Cutler, Cutler, Da Silva, Dadachova, Dadachova, Dague, Dan, De Las Peñas, Del Poeta, DeMarini, Dennehy, Doering, Domer, Douglas, Douglas, Duro, Eisenhaber, Eisenman, Ene, Erwig, Fairlamb, Fernandes, Firon, Fleet, Fontaine, Frieman, Fu, Gagnon-Arsenault, García, García, Gilbert, Glasgow, Gravelat, Gresnigt, Groot, Groot, Groot, Groot, Hall, Hancock, Henry, Herrero, Hiller, Hilpert, Hohl, Hoyer, Hurtado-Guerrero, Ibrahim, Iorio, Irazoqui, Ito, Johnson, Kanetsuna, Karababa, Kaur, Kim, Klis, Klis, Klutts, Kozubowski, Kozubowski, Lamaris, Langfelder, Larsen, Latge, Latgé, Lee, Lee, Lee, Lenardon, Lenardon, Lesage, Levin, Li, Li, Li, Lipschutz, Lombard, Ma, Ma, MacCallum, Machesky, Macho, Martinez, Marty, Martín-Cuadrado, McFadden, Mentlak, Money, Money, Morelle, Morozov, Mouyna, Mouyna, Moyrand, Munro, Munro, Munro, Müller, Netea, Nett, Nobile, Norice, Nosanchuk, Nosanchuk, Odds, Oliveira-Garcia, Oliveira-Garcia, Ostrosky-Zeichner, Paolo, Paris, Park, Perlin, Piotrowski, Pitarch, Popolo, Pérez, Rachini, Rajendran, Rappleye, Rappleye, Rauceo, Reese, Reese, Reese, Reid, Reinoso-Martín, Rispail, Román, Roncero, Rowbottom, Sandini, Schorr, Schuster, Seidl, Selvaggini, Sendid, Shahinian, Sheppard, Sohn, Sorgo, Spellberg, Staab, Steinbach, Steinbach, Steinberg, Steinberg, Stynen, Sudbery, Sundstrom, Sánchez-Vallet, Thompson, Torosantucci, Treitschke, Tsai, Urban, Valdivia, Vargas-Muñiz, Veerdonk, Virag, Wagener, Walker, Walker, Walker, Walton, Weber, Wessels, Wessels, Wheeler, Wheeler, Wiederhold, Wozniak, Wösten, Xin, xSchuster, Yin, Yoneda, Zaragoza, Zarnowski, Zipfel, Zupancic   +215 more
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Seaweed Hydrocolloid Production: An Update on Enzyme Assisted Extraction and Modification Technologies [PDF]

, 2015
Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications.
Ale, Marcel Tutor, Meyer, Anne S., Rhein-Knudsen, Nanna   +2 more
core   +2 more sources

Metabolic mechanism of mannan in a ruminal bacterium, Ruminococcus albus, involving two mannoside phosphorylases and cellobiose 2-epimerase: discovery of a new carbohydrate phosphorylase, β-1,4-mannooligosaccharide phosphorylase.

The Journal of biological chemistry, 2013
Ruminococcus albus is a typical ruminal bacterium digesting cellulose and hemicellulose. Cellobiose 2-epimerase (CE; EC 5.1.3.11), which converts cellobiose to 4-O-β-D-glucosyl-D-mannose, is a particularly unique enzyme in R. albus, but its physiological function is unclear.
Kawahara, Ryosuke, Saburi, Wataru, Odaka, Rei, Taguchi, Hidenori, Ito, Shigeaki, Mori, Haruhide, Matsui, Hirokazu   +6 more
openaire   +3 more sources

Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis [PDF]

, 2006
Metabolic engineering has recently been embraced as an effective tool for developing whole-cell biocatalysts for oligosaccharide and polysaccharide synthesis.
Anne Ruffing, Rachel Chen
core   +1 more source