Results 21 to 30 of about 1,312 (98)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Gut Microbiota Alterations in Myelodysplastic Neoplasms Are Associated With Immune Dysfunction and the Therapeutic Mechanism of Hypomethylating Agents

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Myelodysplastic neoplasms (MDS) represent a group of heterogeneous clonal disorders characterized by immune dysregulation in their pathogenesis. Gut microbiota dysbiosis plays a critical role in immune modulation. Methods We collected the fecal samples of 23 newly diagnosed MDS, 10 hypomethylating agents (HMA) treated MDS and 13 age
Zhongxun Shi, Fei Huang, Chengrong Luo, Lu Yang, Yu Chen, Chun Qiao, Rong Wang, Yan Wang, Yining Yan, Linlin Wang, Lei Fan, Wenyi Shen   +11 more
wiley   +1 more source

Potential Mechanism of Paenibacillus kribbensis in Boosting Sesame Productivity and Pathogen Defense Through Metabolic Reprogramming of Flavonoid and Carbon Fixation Pathways

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
This study demonstrates that the microbial agent HTB enhances sesame yield by 30% and disease resistance by modulating flavonoid biosynthesis, photosynthetic carbon fixation, and fatty acid synthesis. These integrated mechanisms provide a sustainable strategy for improving crop productivity and resilience.
Sisi Liao, Wenhua Zhao, Jianchun Liu, Yongtai Xu, Mingwei Liu, Erxun Zhou, Yiming Zhu, Jiaqi Yang, Lingtao Duan, Bo Lan, Changfa Yin, Nauman Ahmed, Yingqing Yang, Canwei Shu   +13 more
wiley   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

Engineering Chondroitinase‐Free Baculovirus‐Insect Cell Expression System for Efficient Synthesis of Chondroitin Sulphates

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
An engineered baculovirus‐insect cell platform produces chondroitinase‐free sulfotransferases, enabling efficient synthesis of chondroitin sulphates. ABSTRACT Owing to the high expression levels, proper protein folding and post‐translational modifications, baculovirus‐insect cell expression system is an ideal platform for producing active chondroitin ...
Junyue Li, Yuqing Tian, Lihe She, Zhangliang Liu, Yingying Zhou, Yanyan Wang, Jihui Zhang, Leilei Zhu, Huarong Tan, Jine Li   +9 more
wiley   +1 more source

The Basic Helix–Loop–Helix Transcription Factors UvBhlh1 and UvBhlh6 Coordinate Virulence in the Rice False Smut Fungus Ustilaginoidea virens

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
Transcription factors UvBhlh1 and UvBhlh6 are essential for early infection and virulence in Ustilaginoidea virens. These two proteins form a heterodimer that cooperatively regulates downstream target genes during pathogenesis. ABSTRACT Ustilaginoidea virens is the causal agent of rice false smut, a devastating and globally widespread fungal disease ...
Huijuan Cao, Hao Gong, Xiaohong Huang, Jialin Lei, Mina Yu, Xiayan Pan, Tianqiao Song, Junjie Yu, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yongfeng Liu   +11 more
wiley   +1 more source

Involvement of the Streptococcus mutans PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division. [PDF]

Glycobiology, 2023
Andresen S, de Mojana di Cologna N, Archer-Hartmann S, Rogers AM, Samaddar S, Ganguly T, Black IM, Glushka J, Ng KKS, Azadi P, Lemos JA, Abranches J, Szymanski CM.   +12 more
europepmc   +1 more source

A Novel D-Psicose 3-Epimerase from Halophilic, Anaerobic Iocasia fonsfrigidae and Its Application in Coconut Water. [PDF]

Int J Mol Sci, 2023
Wulansari S, Heng S, Ketbot P, Baramee S, Waeonukul R, Pason P, Ratanakhanokchai K, Uke A, Kosugi A, Tachaapaikoon C.   +9 more
europepmc   +1 more source

Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis. [PDF]

J Biol Chem, 2023
Thoden JB, McKnight JO, Kroft CW, Jast JDT, Holden HM.   +4 more
europepmc   +1 more source

Metabolic Mechanism of Mannan in a Ruminal Bacterium, Ruminococcus albus, Involving Two Mannoside Phosphorylases and Cellobiose 2-Epimerase : Discovery of a New Carbohydrate Phosphorylase, β-1,4-Mannooligosaccharide Phosphorylase

Metabolic Mechanism of Mannan in a Ruminal Bacterium, Ruminococcus albus, Involving Two Mannoside Phosphorylases and Cellobiose 2-Epimerase : Discovery of a New Carbohydrate Phosphorylase, β-1,4-Mannooligosaccharide Phosphorylase
Ruminococcus albus is a typical ruminal bacterium digesting cellulose and hemicellulose. Cellobiose 2-epimerase (EC 5.1.3.11, CE), which converts cellobiose to 4-O-β-D-glucosyl-D-mannose, is a particularly unique enzyme in R. albus, but its physiological function is unclear.
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