Results 31 to 40 of about 1,848,692 (283)

Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential

Frontiers in Chemistry, 2022
Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix.
Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Yujing Zhang, Xing Yu   +7 more
doaj   +1 more source

Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification

Biomolecules, 2020
Herein, we report the production of a recombinant Tepary bean lectin (rTBL-1), its three-dimensional (3D) structure, and its differential recognition for cancer-type glycoconjugates.
Dania Martínez-Alarcón, Annabelle Varrot, Elaine Fitches, John A. Gatehouse, Min Cao, Prashant Pyati, Alejandro Blanco-Labra, Teresa Garcia-Gasca   +7 more
doaj   +1 more source

Functional characterisation and comparative analysis of two C-type lectins with different key motifs from mud crab

Aquaculture Reports, 2022
C-type lectins are pattern recognition receptors (PRRs) involved in innate immunity. They possess one or more carbohydrate recognition domains (CRDs) belonging to Ca2+-dependent carbohydrate binding proteins.
Jingwen Liu, Xiaocong Lou, Yuying Yang, Xiaoyuan Zheng, Yunkai Zhang, Peng Zhou, Shun Yang, Mengmeng Huang, Hui Fei   +8 more
doaj   +1 more source

Antibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure.

, 2015
Carbohydrate-protein recognition is vital to many processes in health and disease. In particular, elucidation of the structural basis of carbohydrate binding is important to the development of oligosaccharides and oligosaccharide mimetics as vaccines for
Mark Agostino, Yuriev, E., Agostino, M., Dingjan, T., Ramsland, Paul, Tamir Dingjan, Paul A. Ramsland, Elizabeth Yuriev   +7 more
core   +2 more sources

Molecular architecture with carbohydrate functionalized β-peptides adopting 314-helical conformation

Beilstein Journal of Organic Chemistry, 2014
Carbohydrate recognition is essential in cellular interactions and biological processes. It is characterized by structural diversity, multivalency and cooperative effects.
Nitin J. Pawar, Navdeep S. Sidhu, George M. Sheldrick, Dilip D. Dhavale, Ulf Diederichsen   +4 more
doaj   +1 more source

Galectins: a key intersection between glycobiology and immunology

Brazilian Journal of Medical and Biological Research, 1999
Galectins are a family of evolutionarily conserved animal lectins, widely distributed from lower invertebrates to mammals. They share sequence and structure similarities in the carbohydrate recognition domain and specificity for polylactosamine-enriched ...
G.A. Rabinovich, C.M. Riera, C.A. Landa, C.E. Sotomayor   +3 more
doaj   +1 more source

Structural Basis of Carbohydrate Recognition by Calreticulin [PDF]

Journal of Biological Chemistry, 2010
The calnexin cycle is a process by which glycosylated proteins are subjected to folding cycles in the endoplasmic reticulum lumen via binding to the membrane protein calnexin (CNX) or to its soluble homolog calreticulin (CRT). CNX and CRT specifically recognize monoglucosylated Glc(1)Man(9)GlcNAc(2) glycans, but the structural determinants underlying ...
Guennadi, Kozlov, Cosmin L, Pocanschi, Angelika, Rosenauer, Sara, Bastos-Aristizabal, Alexei, Gorelik, David B, Williams, Kalle, Gehring   +6 more
openaire   +2 more sources

The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis

Molecules, 2015
Lectins are a group of proteins with carbohydrate recognition activity. Lectins are categorized into many families based on their different cellular locations as well as their specificities for a variety of carbohydrate structures due to the features of ...
Yang Liu, Jianying Liu, Xiaojing Pang, Tao Liu, Zhijie Ning, Gong Cheng   +5 more
doaj   +1 more source

Parameter sweep workflows for modelling carbohydrate recognition

, 2010
Carbohydrate recognition is a phenomenon critical to a number of biological functions in humans. Understanding the dynamic behaviour of oligosaccharides should help in the discovery of the mechanisms which lead to specific and selective recognition of ...
Kiss, T., Greenwell, P., Terstyanszky, G., Weingarten, N., Heindl, H.   +4 more
core   +1 more source

Animal lectins as cell adhesion molecules [PDF]

, 1998
Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
core   +1 more source