Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan+12 more
wiley +1 more source
Nonstructural Carbohydrate and Digestibility Patterns in Orchardgrass Swards during Daily Defoliation Sequences Initiated in Evening and Morning [PDF]
T. C. Griggs+3 more
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Genomic characterization and probiotic assessment of Bifidobacterium breve JKL2022 with strain-specific CLA-converting properties. [PDF]
Elnar AG, Eum B, Kim GB.
europepmc +1 more source
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu+11 more
wiley +1 more source
Novel Lectins from <i>Bauhinia</i> with Differential <i>N-</i>Glycan Binding Profiles. [PDF]
Osterne VJS+11 more
europepmc +1 more source
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao+27 more
wiley +1 more source
Amino-Acid Sequence of an Allotype b4 Light Chain from a Rabbit Antibody to Streptococcal Carbohydrate [PDF]
K. C. S. Chen+2 more
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Boosting secretion of starch-converting enzymes from Priestia koreensis HL12 and its application in non-thermal cassava pulp saccharification process for maltooligosaccharides synthesis. [PDF]
Prongjit D+5 more
europepmc +1 more source
A visible‐light‐mediated method has been developed for the direct conversion of biomass into formate at ambient temperature and atmospheric pressure. This approach achieves the selective generation of hydroxyl radicals, which subsequently transform sugars, cellulose, and hemicellulose into formate.
Tong Zhang+7 more
wiley +1 more source
Prediction of protein-carbohydrate binding sites from protein primary sequence [PDF]
Quazi Farah Nawar+3 more
openalex +1 more source