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Asymmetric Synthesis of an Atropisomeric β-Carboline via Regioselective Intermolecular Rh(I)-Catalyzed [2 + 2 + 2] Cyclotrimerization. [PDF]

open access: yesTetrahedron Lett
Hughes RR   +8 more
europepmc   +1 more source
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Mononitro-?-carbolines

Chemistry of Heterocyclic Compounds, 1971
By the direct nitration of harmane and 1,3-dimethyl-, 1-ethyl-, 1-n-propyl-, and 1-isopropyl-β-carbolines with concentrated nitric acid or a mixture of nitric and acetic acids, 6- and 8-nitro-1-alkyl-β-carbolines have been obtained. A chromatographic method for separating the nitration products on alumina is proposed.
A. N. Lomakin, I. V. Terent'eva
openaire   +1 more source

Antischistosomal tetrahydro-γ-carboline sulfonamides

Bioorganic & Medicinal Chemistry Letters, 2022
We discovered tetrahydro-γ-carboline sulfonamides as a new antischistosomal chemotype. The aryl sulfonamide and tetrahydro-γ-carboline substructures were required for high antischistosomal activity. Increasing polarity improved solubility and metabolic stability but decreased antischistosomal activity. We identified two compounds with IC50 values
Rongguo Ren   +8 more
openaire   +3 more sources

Chromatography of β-carbolines

Journal of Chromatography A, 1967
Abstract Chromatography of a series of seventy-three β-carbolines was carried out on both paper and thin-layer plates in acidic, basic, and neutral solvents. The best solvent for the separation is the neutral and polar solvent such as chloroform-methanol on thin-layer chromatography with Silica Gel G.
W M, McIsaac   +3 more
openaire   +2 more sources

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