Results 51 to 60 of about 11,242 (227)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Carbon Ion Radiotherapy for Unresectable Sacral Chordomas [PDF]

Clinical Cancer Research, 2004
Abstract Purpose: The purpose is to evaluate the efficacy and toxicity of carbon ion radiotherapy for unresectable sacral chordomas. Experimental Design: We performed a retrospective analysis of 30 patients with unresectable sacral chordomas treated with carbon ion radiotherapy at the Heavy Ion Medical Accelerator in Chiba,
Reiko, Imai, Tadashi, Kamada, Hiroshi, Tsuji, Takeshi, Yanagi, Masayuki, Baba, Tadaaki, Miyamoto, Shingo, Kato, Susumu, Kandatsu, Jun-etsu, Mizoe, Hirohiko, Tsujii, Shin-ichiro, Tatezaki   +10 more
openaire   +2 more sources

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Cancer Medicine, 2018
Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution.
Reiko Imai, Tadashi Kamada, Nobuhito Araki, and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas   +3 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Clinical Results of Carbon Ion Radiotherapy at NIRS [PDF]

Journal of Radiation Research, 2007
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which was then the world's only heavy ion accelerator complex dedicated to medical use in a hospital environment. Among several types of ion species, we have chosen carbon ions for cancer therapy because they had the most optimal properties in terms of ...
Hirohiko, Tsujii, Junetsu, Mizoe, Tadashi, Kamada, Masayuki, Baba, Hiroshi, Tsuji, Hirotoshi, Kato, Shingo, Kato, Shigeru, Yamada, Shigeo, Yasuda, Tatsuya, Ohno, Takeshi, Yanagi, Reiko, Imai, Kenji, Kagei, Hiroyuki, Kato, Ryusuke, Hara, Azusa, Hasegawa, Mio, Nakajima, Norio, Sugane, Noriaki, Tamaki, Ryo, Takagi, Susumu, Kandatsu, Kyosan, Yoshikawa, Riwa, Kishimoto, Tadaaki, Miyamoto   +23 more
openaire   +2 more sources

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Nanoscale Research Letters, 2019
Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and ...
Feifei Li, Zihou Li, Xiaodong Jin, Yan Liu, Ping Li, Zheyu Shen, Aiguo Wu, Xiaogang Zheng, Weiqiang Chen, Qiang Li   +9 more
doaj   +1 more source

Benchmarking of FLUKA production cross sections of positron emission tomography isotopes for in-vivo range verification in hadron therapy [PDF]

EPJ Web of Conferences, 2020
Protons and carbon ions have been extensively used for radiotherapy treatments, and in comparison to conventional radiotherapy, they allow a more conformal dose to the target tumor, especially in case of deep-seated tumors.
Aricò Giulia, Battistoni Giuseppe, Cerutti Francesco, Horst Felix, Mairani Andrea, Schuy Christoph, Weber Uli, Ferrari Alfredo   +7 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

The Emerging Potential of Multi-Ion Radiotherapy

Frontiers in Oncology, 2021
Research into high linear energy transfer (LET) radiotherapy now spans over half a century, beginning with helium and deuteron treatment in 1952 and today ranging from fast neutrons to carbon-ions.
Daniel K. Ebner, Steven J. Frank, Taku Inaniwa, Shigeru Yamada, Toshiyuki Shirai   +4 more
doaj   +1 more source