Results 81 to 90 of about 11,242 (227)

Overview of Carbon-ion Radiotherapy

Journal of Physics: Conference Series, 2017
The outcome of radiotherapy depends on potential efficiency of accelerators and their related accessories. In charged particle therapy before the 1990s, accelerators that were primarily installed for physics research had been shared, which however had limited flexibility for clinical use.
openaire   +1 more source

Carbon ion radiotherapy for chondrosarcoma

Carbon ion radiotherapy for chondrosarcoma
Purpose: Chondrosarcoma is the second most frequent primary malignant bone tumor. Surgery has been considered as the main form of treatment for chondrosarcoma, and the definitive en bloc resection of tumor is mandatory to obtain long term disease free survival. However, radical surgical intervention has been associated with substantial morbidities. Due
openaire   +2 more sources

A rare case of lacrimal gland adenocarcinoma successfully treated with carbon ion radiotherapy

Radiology Case Reports
Primary malignant tumors of the lacrimal gland are very rare. The standard treatment typically involves wide surgical excision, which may include orbital bone resection and enucleation of the eyeball, followed by adjuvant radiotherapy.
Caterina Benedetto, MD, Ugo Barbaro, MD, Carmelo Anfuso, MD, Fabio Italiano, MD, Danilo Caudo, MD, Fabiana Giacò, MD, Giuseppe Cicero, MD   +6 more
doaj   +1 more source

Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: The CINDERELLA trial

BMC Cancer, 2010
Background Treatment of patients with recurrent glioma includes neurosurgical resection, chemotherapy, or radiation therapy. In most cases, a full course of radiotherapy has been applied after primary diagnosis, therefore application of re-irradiation ...
Haselmann Renate, Haberer Thomas, Jäkel Oliver, Habermehl Daniel, Rieken Stefan, Edler Lutz, Burkholder Iris, Combs Stephanie E, Unterberg Andreas, Wick Wolfgang, Debus Jürgen   +10 more
doaj   +1 more source

Superior tumor cell killing by oxygen ion beam irradiation compared to carbon ions and photons in pancreatic Cancer cells – An in vitro investigation

Clinical and Translational Radiation Oncology
Pancreatic cancer remains one of the most treatment-refractory malignancies, displaying profound resistance to chemotherapy and radiotherapy. While the benefit of photon radiotherapy remains debated, heavy-ion modalities such as carbon ions show promise ...
Lixin Mai, Aleksei Smirnov, Michael M. Allers, Zhengyang Song, Muzi Liu, Thuy Trinh, Stephan Brons, Fabian Weykamp, Jakob Liermann, Ramon Lopez Perez, Jürgen Debus, Peter E. Huber, Jonathan M. Schneeweiss   +12 more
doaj   +1 more source

Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: The PROMETHEUS-01 trial

BMC Cancer, 2011
Background Treatment options for patients with advanced hepatocellular carcinoma (HCC) are often limited. In most cases, they are not amenable to local therapies including surgery or radiofrequency ablation. The multi-kinase inhibitor sorafenib has shown
Jäkel Oliver, Burkholder Iris, Edler Lutz, Schmidt Jan, Ganten Tom, Habermehl Daniel, Combs Stephanie E, Haberer Thomas, Debus Jürgen   +8 more
doaj   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Immunomodulatory Nanozymes as Programmable Redox–Immune Set‐Point Regulators

Small, EarlyView.
Conceptual phase space linking reactive oxygen species level/dynamics to immune state, with pathological set‐points for chronic inflammation, tumor escape, and degeneration contrasted against a central healthy redox–immune set‐point. Buffering and amplifying nanozymes are depicted as devices that dial redox tone up or down to steer diseased ...
Sumi Choi, Minjeong Kim, Sang Jin Lee, Su‐Hwan Kim   +3 more
wiley   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source