Results 41 to 50 of about 18,543,558 (211)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Soil microbial carbon use efficiency and the constraints

Annals of Microbiology
Background Microbial contributions to soil organic carbon formation have received increasing attention, and microbial carbon use efficiency is positively correlated with soil organic carbon storage.
Run Dang, Jian Liu, Eric Lichtfouse, Lifeng Zhou, Meng Zhou, Leilei Xiao   +5 more
doaj   +1 more source

Impact of intercropping on the coupling between soil microbial community structure, activity, and nutrient-use efficiencies [PDF]

PeerJ, 2019
Sugarcane-soybean intercropping has been widely used to control disease and improve nutrition in the field. However, the response of the soil microbial community diversity and structure to intercropping is not well understood.
Tengxiang Lian, Yinghui Mu, Jian Jin, Qibin Ma, Yanbo Cheng, Zhandong Cai, Hai Nian   +6 more
doaj   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Dispersal shapes compositional and functional diversity in aquatic microbial communities

mSystems
Segregation and mixing shape the structure and functioning of aquatic microbial communities, but their respective roles are challenging to disentangle in field studies.
Angel Rain-Franco, Alizée Le Moigne, Lucas Serra Moncadas, Marisa O. D. Silva, Adrian-Stefan Andrei, Jakob Pernthaler   +5 more
doaj   +1 more source

Substituting Far-Red for Traditionally Defined Photosynthetic Photons Results in Equal Canopy Quantum Yield for CO2 Fixation and Increased Photon Capture During Long-Term Studies: Implications for Re-Defining PAR

Frontiers in Plant Science, 2020
Far-red photons regulate shade avoidance responses and can have powerful effects on plant morphology and radiation capture. Recent studies have shown that far-red photons (700 to 750 nm) efficiently drive photosynthesis when added to traditionally ...
Shuyang Zhen, Bruce Bugbee
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Soil Nematode-Mediated Carbon and Energy Fluxes Along a Continental Gradient in Arid Ecosystems

Soil Systems
Environmental gradients associated with continentality shape terrestrial ecosystems by modifying biodiversity patterns, community structure, and ecosystem functioning. In arid ecosystems, where water and thermal constraints are pronounced, soil organisms
Amina Braimi, Hinde Benjlil, Ilyass Filali Alaoui, Tayeb Obidari, Amine Idhmida, Mouna Belmouden, Sarhane Larbi, ElMehdi Elhadda, Hajar Issouktane, Mohamed Ait Hamza, Abdelhamid El Mousadik, Fouad Msanda, Sergio Saia, El Hassan Mayad   +13 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source