Results 61 to 70 of about 1,297,385 (298)

How Virginia Can Meet Its Clean Power Plan Targets [PDF]

open access: yes, 2015
In August 2015, the U.S. Environmental Protection Agency (EPA) finalized the Clean Power Plan (CPP), the first-ever carbon pollution standards for existing power plants.
Kristin Meek   +2 more
core  

Assessment of district scale ecosystem health in India using multi decadal carbon and water use efficiencies

open access: yesDiscover Geoscience
Ecosystem health assessments are critical for understanding ecosystem functioning under increasing climatic and anthropogenic stress, particularly across India’s heterogeneous landscapes. Here, we present a district-scale assessment (n = 640) integrating
Abhishek Chakraborty   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Carbon Free Boston: Energy Technical Report [PDF]

open access: yes, 2019
Part of a series of reports that includes: Carbon Free Boston: Summary Report; Carbon Free Boston: Social Equity Report; Carbon Free Boston: Technical Summary; Carbon Free Boston: Buildings Technical Report; Carbon Free Boston: Transportation ...
Cleveland, Cutler J.   +4 more
core  

Dispersal shapes compositional and functional diversity in aquatic microbial communities

open access: yesmSystems
Segregation and mixing shape the structure and functioning of aquatic microbial communities, but their respective roles are challenging to disentangle in field studies.
Angel Rain-Franco   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Morphological and functional effects of graphene on the synthesis of uranium carbide for isotopes production targets [PDF]

open access: yes, 2018
The development of tailored targets for the production of radioactive isotopes represents an active field in nuclear research. Radioactive beams find applications in nuclear medicine, in astrophysics, matter physics and materials science.
Amador-Celdran, P.   +7 more
core   +1 more source

Does plant community plasticity mediate microbial homeostasis?

open access: yesEcology and Evolution, 2020
Microbial homeostasis—constant microbial element ratios along resource gradients—is a core ecological tenet, yet not all systems display homeostasis.
Kate M. Buckeridge, Jennie R. McLaren
doaj   +1 more source

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