Results 51 to 60 of about 18,543,558 (211)

Vegetation Restoration Alters Soil Microbial Carbon Use Efficiency via Key Soil Properties and Generalist Communities in Karst Rocky Desertification

Agronomy
Soil microbial carbon use efficiency (CUE) is an essential metric for assessing soil carbon cycling efficiency. In contemporary biogeochemical models, microbial CUE is often treated as a constant, but it is intricately regulated by biotic and abiotic ...
Shiyao Wu, Xingyan Chen, Shengnan Li, Jiahai Wu, Yongkuan Chi   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Long‐Term Active Rather than Passive Restoration Promotes Soil Organic Carbon Accumulation by Alleviating Microbial Nitrogen Limitation in an Extremely Degraded Alpine Grassland

Advanced Science
Grassland degradation disrupts microbial nutrient cycling, yet the role of nitrogen (N) limitation in regulating soil organic carbon (SOC) dynamics during restoration remains poorly understood.
Jinchao Gong, Feida Sun, Jingjing Wu, Shijie Zhou, Yue Xiu, Linlin Li, Tahmina Kausar, Zhouwen Ma, Jiqiong Zhou, Lin Liu, Yongxing Cui, Jordi Sardans, Josep Peñuelas, Ahmed Elrys, Ji Chen, Yanfu Bai   +15 more
doaj   +1 more source

Does plant community plasticity mediate microbial homeostasis?

Ecology and Evolution, 2020
Microbial homeostasis—constant microbial element ratios along resource gradients—is a core ecological tenet, yet not all systems display homeostasis.
Kate M. Buckeridge, Jennie R. McLaren
doaj   +1 more source

Land-Use Change and Carbon Sinks [PDF]

When and if the United States chooses to implement a greenhouse gas reduction program, it will be necessary to decide whether carbon sequestration policies — such as those that promote forestation and discourage deforestation — should be part of the ...
Plantinga, Andrew, Stavins, Robert, Lubowski, Ruben   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Active microbial population dynamics and life strategies drive the enhanced carbon use efficiency in high-organic matter soils

mBio
Microbial carbon use efficiency (CUE) is a critical parameter that controls carbon storage in soil, but many uncertainties remain concerning adaptations of microbial communities to long-term fertilization that impact CUE.
Qicheng Xu, Ling Li, Junjie Guo, Hanyue Guo, Manqiang Liu, Shiwei Guo, Yakov Kuzyakov, Ning Ling, Qirong Shen   +8 more
doaj   +1 more source