Results 141 to 150 of about 335,699 (292)

Prostate tumor immune microenvironment changes following immunotherapy shared by patients who developed anti-tumor response or immune-related adverse events

OncoImmunology
Checkpoint inhibitors targeting PD-1/PD-L1 have revolutionized cancer immunotherapy, yet their efficacy in prostate cancer has been limited. We previously reported a clinical trial (NCT02499835) evaluating PD-1 blockade combined with an anti-tumor DNA ...
Ichwaku Rastogi, Douglas G. McNeel
doaj   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

L’imprégnation des mécanismes tendant à favoriser l’atténuation des changements climatiques au travers de la gestion des tourbières du bassin du Congo [PDF]

Mouvements et Enjeux Sociaux
De nos jours, l’impact négatif des effets des changements climatiques aussi bien sur la biodiversité que sur l’humain ne peut être remis en cause. Plusieurs situations s’observent en ce sens, entraînant parfois des catastrophes naturelles.
Glodie KINSEMI MALAMBU
doaj  

Subclonal response heterogeneity to define cancer organoid therapeutic sensitivity

Scientific Reports
Tumor heterogeneity is predicted to confer inferior clinical outcomes with precision-based strategies, however, modeling heterogeneity in a manner that still represents the tumor of origin remains a formidable challenge.
Jeremy D. Kratz, Shujah Rehman, Katherine A. Johnson, Amani A. Gillette, Aishwarya Sunil, Peter F. Favreau, Cheri A. Pasch, Devon Miller, Lucas C. Zarling, Austin H. Yeung, Linda Clipson, Samantha J. Anderson, Alyssa K. Steimle, Carley M. Sprackling, Kayla K. Lemmon, Daniel E. Abbott, Mark E. Burkard, Michael F. Bassetti, Jens C. Eickhoff, Eugene F. Foley, Charles P. Heise, Randall J. Kimple, Elise H. Lawson, Noelle K. LoConte, Sam J. Lubner, Daniel L. Mulkerin, Kristina A. Matkowskyj, Cristina B. Sanger, Nataliya V. Uboha, Sean J. Mcilwain, Irene M. Ong, Evie H. Carchman, Melissa C. Skala, Dustin A. Deming   +33 more
doaj   +1 more source

Skeletal muscle myosin heavy chain fragmentation following exercise may be linked to post‐exercise inflammation and remodelling

Experimental Physiology, EarlyView.
Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHCfrag) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, and/or specific gene expression signatures ...
Dakota R. Tiede, Diego Bittencourt, J. Max Michel, Daniel L. Plotkin, Madison L. Mattingly, Derick A. Anglin, Christopher G. Vann, Zachary A. Graham, Timothy J. Broderick, Marcas M. Bamman, Michael D. Roberts   +10 more
wiley   +1 more source

Messenger RNA and Plasmid DNA Vaccines for the Treatment of Cancer

Vaccines
Immunotherapy is now an established therapy for nearly a third of patients with cancer. Most therapies, typically using cytokines or checkpoint blockade therapy, rely on global activation of immune effector cells.
Jena E. Moseman, Daeun Shim, Donghwan Jeon, Ichwaku Rastogi, Kaitlyn M. Schneider, Douglas G. McNeel   +5 more
doaj   +1 more source

Addressing Heterogeneity in Binge Eating Disorder: A Cluster Analysis Approach Based on Age of Onset, Clinical and Psychopathological Features

European Eating Disorders Review, Volume 34, Issue 2, Page 375-387, March 2026.
ABSTRACT Objective This study investigates clinical heterogeneity in patients with binge eating disorder (BED) and its association with treatment outcomes. Methods A two‐step cluster analysis was conducted on a clinical sample of 196 BED patients, using an agglomerative hierarchical procedure based on both categorical and quantitative measures ...
Lucía Camacho‐Barcia, Lia T. Sánchez‐Salido, Jessica Jiménez del Toro, Roser Granero, Isabel Sánchez, Kim Supit, Nadia Micali, Katrin Elisabeth Giel, Susana Jiménez‐Murcia, Stephan Zipfel, Fernando Fernández‐Aranda   +10 more
wiley   +1 more source

Biomasse aérienne et stockage de carbone de dix essences végétales dominantes du massif forestier de Kikungu, RD Congo

Revue Marocaine des Sciences Agronomiques et Vétérinaires
L'étude menée dans le massif forestier de Kikungu a porté sur dix essences végétales: Anisophyllea polyneura Floret, Alstonia boonei De Wild., Brachystegia laurentii (De Wild.) Louis, Celtis tessmannii Rendle, Distemonanthus benthamianus Baill ...
Bonaventure MASENS, Cyrille BRIKI, Godé YAYA, Santos KAVUMBU, Jean-Paul Koto-Te-Nyiwa NGBOLUA   +4 more
doaj   +1 more source

First whole genome sequence of a diploid crop wild relative of the Andean tuber “oca”: Annotation and comparative genomic analysis of Oxalis oulophora

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Oxalis oulophora, a diploid species closely related to the octoploid Andean tuber crop oca (Oxalis tuberosa), was selected for whole‐genome sequencing to aid in understanding the origins of polyploidy and domestication in oca and its relatives (crop wild relatives).
Dilrini Vanrooyen, Eve Emshwiller
wiley   +1 more source

Using Linked Emissions Trading Systems to Transform Difficult‐to‐Abate Industries

WIREs Energy and Environment, Volume 15, Issue 1, March 2026.
Linking emissions trading systems (ETSs) limited to a single industry across many countries can facilitate global transformation of the industry. ABSTRACT Emissions trading systems (ETSs) have expanded over the past 20 years to cover over 23% of global GHG emissions. This growth reflects their demonstrated ability to reduce emissions by diverse sources
Erik Haites
wiley   +1 more source