Results 11 to 20 of about 21,848 (142)

Prime-boost vaccination targeting prostatic acid phosphatase (PAP) in patients with metastatic castration-resistant prostate cancer (mCRPC) using Sipuleucel-T and a DNA vaccine

Journal for ImmunoTherapy of Cancer, 2018
Background Prostatic acid phosphatase (PAP) is a prostate tumor antigen, and the target of the only FDA-approved anti-tumor vaccine, sipuleucel-T. We have previously reported in two clinical trials that a DNA vaccine encoding PAP (pTVG-HP) could elicit ...
Ellen Wargowski, Laura E. Johnson, Jens C. Eickhoff, Lauren Delmastro, Mary Jane Staab, Glenn Liu, Douglas G. McNeel   +6 more
doaj   +1 more source

Point and Line to Plane: The Ontography of Carbon Nanomaterials

Cahiers François Viète, 2017
The carbons known today as fullerenes, nanotubes, and graphene were all observed or theorized well before becoming emblematic nanomaterials. However, by the 1990s, their mode of existence was shifted from bench or brand objects to technoscientific ...
Sacha Loeve
doaj   +1 more source

Analytical validation and initial clinical testing of quantitative microscopic evaluation for PD-L1 and HLA I expression on circulating tumor cells from patients with non-small cell lung cancer

Biomarker Research, 2022
Introduction PD-L1 expression in non-small cell lung cancer (NSCLC) predicts response to immune checkpoint blockade, however is an imperfect biomarker given tumor heterogeneity, and the antigen presentation pathway requiring other components including ...
Jennifer L. Schehr, Nan Sethakorn, Zachery D. Schultz, Camila I. Hernandez, Rory M. Bade, Diego Eyzaguirre, Anupama Singh, David J. Niles, Leslie Henderson, Jay W. Warrick, Scott M. Berry, Kaitlin E. Sundling, David J. Beebe, Ticiana A. Leal, Joshua M. Lang   +14 more
doaj   +1 more source

A carbon–carbon hybrid – immobilizing carbon nanodots onto carbon nanotubes

Chemical Science, 2015
The thrust of this work is to integrate small and uniformly sized carbon nanodots (CNDs) with single-walled carbon nanotubes of different diameters as electron acceptors and electron donors, respectively, and to test their synergetic interactions in terms of optoelectronic devices.
Volker Strauss, Johannes T. Margraf, Timothy Clark, Dirk M. Guldi   +3 more
openaire   +5 more sources

PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy

OncoImmunology, 2021
Concurrent blockade of different checkpoint receptors, notably PD-1 and CTLA-4, elicits greater anti-tumor activity for some tumor types, and the combination of different checkpoint receptor inhibitors is an active area of clinical research.
Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro, Douglas G. Mcneel   +3 more
doaj   +1 more source

Increasing the clinical efficacy of NK and antibody-mediated cancer immunotherapy: potential predictors of successful clinical outcome observed in high-risk neuroblastoma

Frontiers in Pharmacology, 2012
Disease recurrence is frequent in high-risk neuroblastoma (NBL) patients even after multimodality aggressive treatment [a combination of chemotherapy, surgical resection, local radiation therapy, autologous stem cell transplantation (ASCT) and cis ...
Tony A. Koehn, Lori L. Scardino, Kory L. Alderson, Amy K. Erbe, Kim A. McDowell, Bartosz eGrzywacz, Jacquelyn A. Hank, Paul Mark Sondel   +7 more
doaj   +1 more source

Impacts environnementaux et socioéconomiques des écosystèmes de mangrove dans le parc national du delta du Saloum  [PDF]

Akofena
Résumé: La mangrove est un écosystème côtier qui fournit non seulement plusieurs services écosystémiques clés aux communautés riveraines mais également contribue largement aux stockages du carbone dans la biomasse racinaire et aérienne à travers la ...
Amath Alioune COUNDOUL
doaj   +1 more source

Estimation du carbone de la mangrove de la Réserve de Biosphère du Delta du Saloum (RBDS) à partir des données d’observation de la terre [PDF]

Revue de Géographie Tropicale et d’Environnement
Depuis les années 70, le changement climatique est devenu un phénomène qui s’accentue de jour en jour et qui est perçu dans les différentes parties du monde.
Moussa SOW; Labaly TOURE ; El Hadji SOW
doaj   +1 more source

Évolution des stocks de carbone en fonction des trajectoires de gestion en zone humide

Sciences, Eaux & Territoires, 2018
Plans de gestion et études d'impact devraient dorénavant inclure les services écosystémiques (SE). Face au changement climatique, la régulation du climat global par le stockage de carbone par les écosystèmes est un SE au cœur des préoccupations. C'est un
O. BARTHOLOMÉE, S. LAVOREL, D. LABARRAQUE, S. GAUCHERAND   +3 more
doaj   +1 more source

Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer

Molecular Oncology, 2020
Centrosome amplification (CA) is a common phenomenon in cancer, promotes genomic stability and cancer evolution, and has been reported to promote metastasis.
Ashok Singh, Ryan A. Denu, Serena K. Wolfe, Jamie M. Sperger, Jennifer Schehr, Tessa Witkowsky, Karla Esbona, Richard J. Chappell, Beth A. Weaver, Mark E. Burkard, Joshua M. Lang   +10 more
doaj   +1 more source