Results 171 to 180 of about 77,334 (297)

Isoxazole-Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies. [PDF]

Molecules
Berber N, Türkeri ÖN, Başoğlu F, Çıkrıkcı K, Ergün A, Gencer N.   +5 more
europepmc   +1 more source

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Beyond Neddylation Inhibition: X‑ray Structures Reveal Carbonic Anhydrase Isoform Selectivity of Pevonedistat. [PDF]

ACS Med Chem Lett
Baroni C, Ferraroni M, Supuran CT, Angeli A.   +3 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Carbonic Anhydrase I and II as Biomarkers and Therapeutic Targets in Human Disease: From Physiology to Clinical Translation. [PDF]

Int J Mol Sci
Sümer A, Şahin S, Menteşe A.
europepmc   +1 more source

Toward Ideal Proximity‐Driven Reactions in Chemical Biology

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
Building on established principles of molecular templation, this perspective explores how molecular recognition can control chemical reactivity in space and time and outlines the design principles of an ideal proximity‐driven reaction for chemical biology.
Dominik Schauenburg
wiley   +1 more source

Parsing the stepwise molecular evolution of C4-associated β-carbonic anhydrase in the genus Flaveria. [PDF]

Plant Physiol
Baros CJ, Saladié M, Beerkens J, Cohen JB, Ng JE, Waters MT, Ludwig M.   +6 more
europepmc   +1 more source

Carbonic anhydrase VIII as a regulator of intracellular calcium signaling: mechanistic insights and implications in human disease. [PDF]

Mol Biol Rep
Aspatwar A.
europepmc   +1 more source

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2166-2171, October 2026.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

Benzoxaboroles Are Inhibitors of the η-Class Carbonic Anhydrase From Plasmodium falciparum. [PDF]

Arch Pharm (Weinheim)
Bonardi A, Wein S, Mustafa M, Cerdan R, de Luca V, Capasso C, Gratteri P, Supuran CT, Nocentini A, Winum JY.   +9 more
europepmc   +1 more source