Results 281 to 290 of about 2,453,486 (333)

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma. [PDF]

Int J Cancer
Fukushima H, Takao S, Furusawa A, Suzuki M, Yang Y, Ricketts CJ, Kano M, Okuyama S, Yamamoto H, Kano M, Ball MW, Choyke PL, Linehan WM, Kobayashi H.   +13 more
europepmc   +1 more source

Carbonic anhydrase IX downregulation linked to disruption of HIF-1, NFκB and STAT3 pathways as a new mechanism of ibuprofen anti-cancer effect. [PDF]

PLoS One
Grossmannova K, Belvoncikova P, Puzderova B, Simko V, Csaderova L, Pastorek J, Barathova M.   +6 more
europepmc   +1 more source

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides. [PDF]

Beilstein J Org Chem
Saeed A, Ehsan S, Zia-Ur-Rehman M, Marshall EM, Loesgen S, Saleem A, Giovannuzzi S, Supuran CT.   +7 more
europepmc   +1 more source

Crystal structure of γ-carbonic anhydrase from the polyextremophilic bacterium Aeribacillus pallidus. [PDF]

Mol Cells
Choi SH, Jin MS.
europepmc   +1 more source

Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen. [PDF]

Cells
Hoffmann S, Berger BT, Lucas LR, Schiele F, Park JE.   +4 more
europepmc   +1 more source

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Carbonic anhydrase activators.

Future Medicinal Chemistry, 2018
Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity ...
C. Supuran
semanticscholar   +5 more sources

Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

Archiv der Pharmazie, 2021
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance.
M. Gümüş, Şemsi N Babacan, Yeliz Demir, Y. Sert, İ. Koca, I. Gülçin   +5 more
semanticscholar   +1 more source

Emerging role of carbonic anhydrase inhibitors.

Clinical science, 2021
Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) was clinically exploited for decades, as most modern diuretics were obtained considering as lead molecule acetazolamide, the prototypical CA inhibitor (CAI). The discovery and characterization of multiple
C. Supuran
semanticscholar   +1 more source

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

Medicinal research reviews (Print), 2020
Carbonic anhydrases (CAs, EC 4.2.1.1) are widely distributed metalloenzymes in both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon dioxide to bicarbonate and H+ ions and play a crucial role in regulating many ...
C. B. Mishra, M. Tiwari, C. Supuran
semanticscholar   +1 more source