Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]
, 2017 Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván +5 more
core +1 more source
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates [PDF]
, 2010 BACKGROUND: The beta-carbonic anhydrase (CA, EC 4.2.1.1) enzymes have been reported in a variety of organisms, but their existence in animals has been unclear.
Gorr, T A +11 more
core +5 more sources
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms [PDF]
, 2016 A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, Atilla +9 more
core +5 more sources
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen +4 more
wiley +1 more source
Effects on the reproductive system in domestic dowl (Gallus domesticus) after embryonic exposure to estrogenic substances [PDF]
, 2007 Environmental pollutants with estrogenic activity have a potential to disrupt oestrogen-dependent developmental processes. Thus, the aim of this thesis was to investigated how embryonic exposure to the estrogenic pollutants EE2 (17 alpha ...
Hermansson, Alexandra
core
Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]
, 2012 Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O. +4 more
core +5 more sources
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT This study investigates the physiological and biochemical responses of a newly isolated microalgal strain, Dictyosphaerium sp. AM‐2024a, identified through 18S rDNA sequencing, under varying environmental conditions and microplastic (MP) interactions.
Khushboo Iqbal +2 more
wiley +1 more source
Chemical Modification of Carbonic Anhydrase II with Acrolein
Journal of Biological Chemistry, 1989 We have reacted acrolein with human carbonic anhydrase II using conditions reported to result in maximal formylethylation of exposed histidine and lysine residues (Pocker, Y., and Janjić, N. (1988) J. Biol. Chem. 263, 6169-6176). Pocker and Janjić proposed that the decrease by 95-98% in the steady-state turnover number for the hydration of CO2 caused ...
C, Tu, G C, Wynns, D N, Silverman
openaire +2 more sources
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source
Journal of Inflammation Research, 2023 Xianqin Song,1 Yu Song,1 Quanping Ma,2 Kehua Fang,3 Xiaotian Chang1 1Medical Research Center of the Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Clinical Laboratory, The fourth People’s Hospital of Jinan ...
Song X, Song Y, Ma Q, Fang K, Chang X
doaj