Results 141 to 150 of about 27,386 (335)

Efficacy of a K+ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis

open access: yesMuscle &Nerve, EarlyView.
Pretreatment with an agonist of Kv7 potassium channels (XEN1101) protects the soleus muscle from a loss of force during a 2 mM K+ challenge, in a mouse model of hypokalemic periodic paralysis. ABSTRACT Introduction/Aims Effective management remains lacking for recurrent episodes of acute weakness in hypokalemic periodic paralysis (HypoPP).
Viktor Chanchykov   +4 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan–Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors

open access: yesScientific Reports
Inhibition of carbonic anhydrases (EC 4.2.1.1, hCAs) is known to be a potential target for treatment of several disorders like epilepsy, glaucoma, obesity, and cancer.
Moniba Sharif   +9 more
doaj   +1 more source

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy [PDF]

open access: bronze, 2012
Alan McIntyre   +12 more
openalex   +1 more source

Mineral Speciation for CO2 Captured by Potassium Hydroxide

open access: yesChemistryOpen, EarlyView.
Multimodal and deconvolution analysis of the crystalline and amorphous mineral products from the rapid capture of CO2 in aqueous, aqueous‐ethanol, and aqueous‐acetone solutions of potassium hydroxide by complementary single‐crystal and powder X‐ray diffraction, and high field 1H, 13C, and 39K NMR, provides new insight into the speciation of both KHCO3‐
Ehsan Ezzatpour Ghadim   +5 more
wiley   +1 more source

Evaluation of Benzenesulfonamide Derivatives; Quinazoline and Sulfonamide Selectively Targeting Carbonic Anhydrase XII for Tumor Microenvironment Modulation in Human Breast Cancer Cells

open access: yesAl-Mustansiriyah Journal of Pharmaceutical Sciences
Tumor cells evolve adaptive mechanisms to function optimally within an acidic microenvironment. This adaptation is driven by the enhanced metabolic activity of tumors, which frequently results in acidosis and hypoxia.
HIBA NABIL MIRAN   +3 more
doaj   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov   +3 more
wiley   +1 more source

Prognostic value of serum carbonic anhydrase IX in Egyptian patients with cirrhosis and/ or hepatocellular carcinoma. [PDF]

open access: bronze, 2023
Heba M. Abd El Latif   +4 more
openalex   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

open access: yesThe Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos   +3 more
wiley   +1 more source

Effects of Glyphosate on the Planktonic Microbiota: An Experimental Approach

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Glyphosate is one of the most widely used herbicides in the world, including in Brazil, and its dispersion through habitats and surface waters can impact entire aquatic ecosystems. However, experimental studies evaluating the effects of pesticides on whole planktonic communities, considering attributes such as richness, density and composition—
Melissa Progênio   +7 more
wiley   +1 more source

ANIDRASI CARBONICA:SINTESI DI SOLFONAMMIDI BENZOTIOPIRANO-PIRIMIDINICHE QUALI POTENZIALI INIBITORI ISOFORMA SELETTIVI [PDF]

open access: yes, 2015
Le anidrasi carboniche (CA) sono una superfamiglia di metallo-enzimi che catalizzano l’interconversione tra anidride carbonica e ione bicarbonato. Ad oggi sono conosciute cinque distinte famiglie genetiche di diversa evoluzione: α-CA, β-CA, γ-CA, δ-CA e ...
PESCAGLINI, SARA
core  

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