Results 1 to 10 of about 90,509 (255)
A novel sulfonamide resistance mechanism by two-component flavin-dependent monooxygenase system in sulfonamide-degrading actinobacteria [PDF]
Environment International, 2019 Sulfonamide-degrading bacteria have been discovered in various environments, suggesting the presence of novel resistance mechanisms via drug inactivation. In this study, Microbacterium sp.
Dae-Wi Kim +2 more
exaly +5 more sources
Pharmacy (Basel, Switzerland), 2019 As one of the earliest developed antimicrobial classes, sulfonamides remain important therapeutic options for the empiric and definitive treatment of various infectious diseases.
Giuseppe Gumina
exaly +5 more sources
An assessment of organic solvent based equilibrium partitioning methods for predicting the bioconcentration behavior of perfluorinated sulfonic acids, carboxylic acids, and sulfonamides [PDF]
, 2009 SPARC, KOWWIN, and ALOGPS octanol-water partitioning (log K~ow~) and distribution (log D) constants were calculated for all C~1~ through C~8~ and the straight chain C~9~ through C~15~ perfluoroalkyl sulfonic acids (PFSAs) and carboxylic acids (PFCAs ...
Kaya Forest, Sierra Rayne
core +4 more sources
Guangdong nongye kexue, 2022 【Objective】With the rapid development of large-scale livestock and poultry breeding industry, the pollution of sulfonamide antibiotics in livestock and poultry manure is becoming more and more prominent.
Weida YU +6 more
doaj +1 more source
Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides
Applied Sciences, 2021 Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of
Ali Irfan +7 more
doaj +1 more source
Biomolecules, 2022 Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing.
Thayssa Tavares da Silva Cunha +7 more
doaj +1 more source
Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues
JACS Au, 2023 Sulfonamides are one of the most important pharmacophores in medicinal chemistry, and sulfonamide analogues have gained substantial interest in recent years. However, the protein interactions of sulfonamides and especially of their analogues are underexplored.
Patrick L. Purder +9 more
openaire +3 more sources
Medical Sciences Forum, 2022 Cancer is a disease that has spread widely throughout the world and requires the development of new anticancer drugs. Curing cancer is a complicated process as the drugs that are used target human cells and cells that have undergone genetic changes and ...
Beata Żołnowska +2 more
doaj +1 more source
Mechanism of C−F Reductive Elimination from Palladium(IV) Fluorides [PDF]
, 2010 The first systematic mechanism study of C−F reductive elimination from a transition metal complex is described. C−F bond formation from three different Pd(IV) fluoride complexes was mechanistically evaluated.
Benitez, Diego +6 more
core +2 more sources
Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists [PDF]
, 2014 A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme.
Copley, R.C.B. +4 more
core +1 more source