Results 11 to 20 of about 50,577 (283)
Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues [PDF]
JACS Au, 2023 Sulfonamides are one of the most important pharmacophores in medicinal chemistry and sulfonamide analogs have gained substantial interest in recent years. However, the protein interactions of sulfonamides and especially of their analogs are underexplored.
Patrick L. Purder +9 more
core +6 more sources
Molecular construction of sulfonamide antisense oligonucleotides [PDF]
, 2019 An efficient and scalable synthesis of new oligonucleotide monomers was developed for replacement of the phosphodiester backbone of RNA by a sulfonamide-containing backbone to enable construction of sulfonamide antisense oligonucleotides (SaASOs). It was
Korotkovs, Valerijs +4 more
core +6 more sources
, 2022 Selective glucocorticoid receptor modulators (SGRMs), which can dissociate the transactivation from the transrepression of the glucocorticoid receptor (GR), are regarded as very promising therapeutics for inflammatory and autoimmune diseases.
Lei Xu (78676) +11 more
core +2 more sources
Sulfonamide−Pyridine-N-oxide Cocrystals
, 2016 Hydrogen-bond motifs for the supramolecular synthesis of sulfonamide−pyridine-N-oxide complexes were derived from the analysis of cocrystal structures of aryl sulfonamides and pyridine-N-oxides.
N. Rajesh Goud (1395406) +2 more
core +7 more sources
Sulfonamides and trimethoprim [PDF]
Expert Review of Anti-infective Therapy, 2009 Sulfonamides and trimethoprim are inexpensive and effective antibacterial drugs that have been used extensively. The use of sulfonamides for systemic use has, however, decreased dramatically for several years, mainly because of resistance development in pathogenic bacteria and allergic side effects. Also the clinical efficiency of trimethoprim has been
openaire +2 more sources
Point Mutations in the folP Gene Partly Explain Sulfonamide Resistance of Streptococcus mutans
International Journal of Microbiology, 2013 Cotrimoxazole inhibits dhfr and dhps and reportedly selects for drug resistance in pathogens. Here, Streptococcus mutans isolates were obtained from saliva of HIV/AIDS patients taking cotrimoxazole prophylaxis in Uganda.
W. Buwembo +4 more
doaj +1 more source
Tạp chí Khoa học Đại học Cần Thơ, 2018 Escherichia coli sinh enzyme beta-lactamases phổ rộng (ESBL-E. coli) là loài vi khuẩn gây nhiều bệnh nguy hiểm cho người và những loài động vật trên cạn. Một số nghiên cứu đã ghi nhận ESBL-E. coli xuất hiện trên cá nuôi và cá tự nhiên, điều đáng quan tâm
Phan Như Ý, Trần Thị Tuyết Hoa
doaj +1 more source
EFSA Journal, 2020 According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance amisulbrom.
European Food Safety Authority (EFSA) +20 more
doaj +1 more source
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis
Nature Communications, 2019 Sulfonamide is in many important drugs yet is rare in nature and little is known about the synthesis of sulfonamide containing antibiotics. Here, the authors report on a detailed analysis of the biosynthesis machineries of the aminoacyl sulfonamide ...
Zhijuan Hu +3 more
doaj +1 more source
Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
Metabolites, 2018 A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Morteza Abdoli +3 more
doaj +1 more source