Results 141 to 150 of about 7,953 (283)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

CO2‐sensitive K+ channel traffic affects stomata and whole‐plant water use

Journal of Integrative Plant Biology, EarlyView.
CO2‐responsive regulation of membrane trafficking influences the density of the potassium ion (K+) channel KAT1 at the plasma membrane. CO2‐sensitive traffic, dependent on trafficking by the SNARE SYP121, impacts stomatal gas exchange and plant growth.
Zhiyi Yu, Sakharam Waghmare, Sahar Farami, Michael R. Blatt, Rucha Karnik   +4 more
wiley   +1 more source

Absence of plastidic carbonic anhydrases affects plant growth but not photosynthesis. [PDF]

Plant Physiol
Moseler A.
europepmc   +1 more source

Boron-containing carbonic anhydrases inhibitors

International audienceOver the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and ...
Giovannuzzi, Simone, Smietana, Michael, Nikitjuka, Anna, Winum, Jean-Yves, Pereira Resende, Bruna Rafaela, Supuran, Claudiu, T, Nocentini, Alessio   +6 more
core   +1 more source

Dietary L‐Tyrosine Sustains Egg Production and Quality by Modulating Promoter CpG Methylation, Gene Expression, and Hormone Profiles in Reproductive Signalling Pathways of Aged Laying Hens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Managing prolactin (PRL)‐mediated reproductive suppression is critical for maintaining egg production in commercial laying hens. L‐tyrosine (TYR), a precursor of dopamine (DA), may counteract age‐related reproductive decline by suppressing PRL, thereby sustaining productivity and egg quality in late‐phase laying hens.
Hasan Hüseyin İpçak
wiley   +1 more source

Role of extracellular carbonic anhydrase in the polar diatom Fragilariopsis cylindrus

New Phytologist, EarlyView.
Summary Diatoms are major primary producers in productive polar oceans, where cold temperatures and high CO2 solubility raise questions as to whether they rely on the CO2‐concentrating mechanism (CCM) to saturate photosynthesis. Knowledge of CCM function will help better predict the sensitivity of diatom primary production to warming and acidifying ...
Meng Li, Jodi N. Young
wiley   +1 more source

Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases. [PDF]

RSC Med Chem
Abbass EM, Ladu F, Mansot J, Noël M, Nocentini A, Sechi M, Supuran CT, Smietana M, Winum JY.   +8 more
europepmc   +1 more source

Rapid dehydration drives a nondiffusional drop in C3 photosynthesis that aligns with phosphate limitation

New Phytologist, EarlyView.
Schematic representation of the causal sequence through which rapid water loss imposes diffusive and nondiffusive restrictions on carbon assimilation. Summary Drought is an abnormally prolonged water deficit posing major challenges to plants. Stomatal closure has long been considered the primary factor limiting photosynthesis during the early stages of
Chandra Bellasio, Daniel Tholen, Hilary Stuart‐Williams, Graham D. Farquhar, Jaume Flexas   +4 more
wiley   +1 more source

Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases. [PDF]

J Med Chem
Nocentini A, Giovannuzzi S, Alterio V, Bonardi A, Barons R, Zalubovskis R, Eldehna WM, Aronne R, Esposito D, Luchinat E, De Simone G, Bartolucci G, Gratteri P, Mori M, Supuran CT.   +14 more
europepmc   +1 more source