Results 171 to 180 of about 2,925,002 (305)

Steroidal A/B-ring fusion as a strategy for isoform-selective inhibition of human carbonic anhydrases. [PDF]

RSC Adv
Brynda J, Kiss A, Pospíšilová K, Kapras V, Sieglová I, Slavíková B, Řezáčová P, Kudová E.   +7 more
europepmc   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Hybrid and Chimeric Heterocycles for the Inhibition of Carbonic Anhydrases. [PDF]

Pharmaceuticals (Basel)
Paoletti N, Giovannuzzi S, Supuran CT.
europepmc   +1 more source

Fibromyxoid Nephrogenic Adenoma Mimicking Renal Cell Carcinoma: A Diagnostic Pitfall in Fine‐Needle Aspiration Cytology

Diagnostic Cytopathology, Volume 54, Issue 10, Page E236-E239, October 2026.
ABSTRACT Nephrogenic adenoma (NA) is a benign lesion of the genitourinary tract that may mimic malignancy both clinically and histologically. The fibromyxoid variant (FMNA), characterized by spindled cells in myxoid stroma, presents additional diagnostic challenges due to its rarity and overlapping features with renal cell carcinoma (RCC).
Jodi Gedallovich, Adebola Adeniyi, Ankur R. Sangoi, Xiaohua Qian, Kelly Ernst   +4 more
wiley   +1 more source

Coumarin- and Dipicolylamine-Terpenoid Hybrids as Selective Carbonic Anhydrases IX and XII Inhibitors: Mechanistic Insights and Selective Anti-Cancer Potential. [PDF]

Pharmaceuticals (Basel)
Saravanan V, Angeli A, Melfi F, Amodio N, Valentino I, Gentile M, D'Agostino I, Muthukumaradoss K, Zengin G, Moi D, Simsek R, Supuran CT, Carradori S.   +12 more
europepmc   +1 more source

Plasma PlGF as a Potential Biomarker in Ramucirumab‐Based Second‐Line Therapy for Advanced Gastroesophageal Adenocarcinoma: Exploratory Biomarker Analysis from the Phase II Part of the RAMIRIS Trial

International Journal of Cancer, Volume 159, Issue 7, Page 1817-1828, 1 October 2026.
Antiangiogenic treatment with ramucirumab is a standard second‐line option in advanced gastric and gastroesophageal junction adenocarcinoma. However, reliable biomarkers are currently lacking. This exploratory biomarker analysis of the RAMIRIS trial suggests that elevated baseline and early on‐treatment levels of the pro‐angiogenic placental growth ...
Jurek Hille, Sylvie Lorenzen, Claudia Pauligk, Victoria Gensch, Peter Thuss‐Patience, Eray Goekkurt, Thomas Ettrich, Florian Lordick, Carsten Bokemeyer, Christian Müller, Peter Reichardt, Martin Sökler, Daniel Pink, Stefan Probst, Thorsten O. Goetze, Salah E. Al‐Batran, Sonja Loges, Melanie Janning   +17 more
wiley   +1 more source

Machine learning-guided discovery of thermophilic carbonic anhydrases from environmental metagenomes. [PDF]

Sci Rep
Pairoh S, Mhuantong W, Boonyapakron K, Yuvaniyama J, Kanokratana P, Bunterngsook B, Lekakarn H, Arunrattanamook N, Laothanachareon T, Champreda V.   +9 more
europepmc   +1 more source

Carbonic Anhydrases: A Superfamily of Ubiquitous Enzymes. [PDF]

Int J Mol Sci, 2023
Capasso C.
europepmc   +1 more source

Hyperpolarized MRI in Oncology—A Review of Clinical Studies and Evaluation of Preclinical Liver Studies

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Hyperpolarized MRI is a promising clinical imaging modality in oncology, offering at least nine imaging contrasts obtainable with hyperpolarized [1‐13C]pyruvate as the injected agent, depending on the tissue and condition under investigation. Preclinical studies suggest that hyperpolarized MRI is warranted for detecting hepatocellular carcinoma within ...
Naama Lev‐Cohain, Jacob Sosna, Rachel Katz‐Brull   +2 more
wiley   +1 more source

Roles of three carbonic anhydrases in <i>in vitro</i> growth, pH homeostasis, metabolism, and intracellular survival of <i>Neisseria gonorrhoeae</i>. [PDF]

FEMS Microbes
Alokabandara SV, Liang HW, Bandara AB.
europepmc   +1 more source