Results 171 to 180 of about 2,875,268 (275)

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases. [PDF]

ACS Med Chem Lett
Onali A, Sanna E, Lupia A, Secci D, Atzeni G, Demuru L, Angeli A, Cottiglia F, Meleddu R, Emmolo R, Corona A, Maccioni E, Supuran CT, Distinto S.   +13 more
europepmc   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

RETRACTED: Sarnella et al. A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity. <i>Int. J. Mol. Sci.</i> 2020, <i>21</i>, 8405. [PDF]

Int J Mol Sci
Sarnella A, D'Avino G, Hill BS, Alterio V, Winum JY, Supuran CT, De Simone G, Zannetti A.   +7 more
europepmc   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Synergistic roles of aquaporin 5 and intra- and extracellular carbonic anhydrases in promoting CO₂ diffusion across the Xenopus oocyte plasma membrane. [PDF]

J Physiol
Wang DK, Moss FJ, Boron WF.
europepmc   +1 more source

Estimating the Sodium Content: A Case Series of Benign and Malignant Renal Tumours Using 23Na‐MRI at 3 T

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
23Na‐MRI at 3 T was applied to estimate TSC in patients with kidney tumours of different pathologies, which are indistinguishable on conventional imaging methods. The apparent TSC was significantly higher in renal oncocytomas (benign) compared to chromophobe renal cell carcinomas (malignant): 162 ± 58 mM vs. 71 ± 2 mM (p < 0.05).
Ines Horvat‐Menih, Jonathan R. Birchall, Maria J. Zamora‐Morales, Alice Bebb, Joshua D. Kaggie, Frank Riemer, Andrew B. Gill, Andrew N. Priest, Marta Wylot, Iosif A. Mendichovszky, Anne Y. Warren, James Jones, James N. Armitage, Thomas J. Mitchell, Grant D. Stewart, Mary A. McLean, Ferdia A. Gallagher   +16 more
wiley   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, Volume 22, Issue 43, 3 August 2026.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Structural Studies of the Dopamine D₄ Receptor Antagonist Sonepiprazole as an Inhibitor of Human Carbonic Anhydrases. [PDF]

ACS Med Chem Lett
Angeli A, Ferraroni M, Capasso C, Supuran CT.   +3 more
europepmc   +1 more source

Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
N. R. Uda, Volker Seibert, F. Stenner-Liewen, P. Müller, P. Herzig, Gabor Gondi, R. Zeidler, M. V. van Dijk, A. Zippelius, C. Renner   +9 more
semanticscholar   +1 more source