Results 41 to 50 of about 552,882 (305)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Synthesis and Structural Characterization of Cobalt Complexes Ligated by N-Methyl(bis(diphenylphosphino)amine)

Molbank
The reaction of the short-bite bis(diphosphino)amine ligand Ph2PN(Me)PPh2 (Medppa) with an equimolar amount of [Co2(CO)8] in toluene solution yielded the diphosphane-bridged complex bis(µ2-carbonyl)(µ-bis(diphenylphosphino)methylamine)-tetracarbonyl ...
Mélaine Wang, Isabelle Jourdain, Michael Knorr, Carsten Strohmann, Annika Schmidt   +4 more
doaj   +1 more source

Scope and Mechanistic Study of the Coupling Reaction of α,β-Unsaturated Carbonyl Compounds with Alkenes: Uncovering Electronic Effects on Alkene Insertion vs Oxidative Coupling Pathways [PDF]

, 2012
The cationic ruthenium-hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4– (1) was found to be a highly effective catalyst for the intermolecular conjugate addition of simple alkenes to α,β-unsaturated carbonyl compounds to give (Z)-selective tetrasubstituted ...
Ackermann L., Ackermann L., Ackermann L., Ackermann L., Anastas P. T., Anastas P. T., Anslyn E. V., Arai T., Beccalli E. M., Berlin J. M., Bernasconi C. F., Chae S. Yi, Colby D. A., Colby D. A., Cristau H.-J., Do W. Lee, Donohoe T. J., Engle K. M., Flynn A. B., Foley N. A., Frantz D. E., Gansäuer A., Gao H., Giri R., Giri R., Guo L.-N., Hartwig J. F., Ho C.-Y., Hojo D., Huang C., Isaacs N. S., Itami K., Jun C.-H., Kakiuchi F., Kakiuchi F., Kakiuchi F., Ki-Hyeok Kwon, Kwon K.-H., Kwon K.-H., Lee D. W., Lee D.-H., Lemay A. B., Liu L., Lu Y., Maryanoff B. E., Matsubara R., Matsuura Y., McKinley N. F., Negishi E., Ni Y., Ogoshi S., Oh H. K., Park S. H., Patureau F. W., Patureau F. W., Patureau F. W., Pintori D. G., Rakshit S., Rakshit S., Sato T., Sheldon R. A., Shen Y., Shi B.-F., Singleton D. A., Stenne B., Strohfeldt K., Stuart D. R., Stuart D. R., Stuart D. R., Su Y., Tang J.-M., Trost B. M., Tsai A. S., Ueyama T., Umeda N., Vorfalt T., Wang F., Wasa M., Wasa M., Weissman H., Weston M. H., Ye M., Yi C. S., Yi C. S., Yokota T., Yu M., Zhang Y.-H., Zhao C., Zhou C., Zhou C., Zhu C.   +90 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Determinação de compostos carbonilados e carboxilados em derivados de petróleo

Química Nova, 2012
Although metals and nitrogen/sulfur compounds have been the main concern of the petroleum industry, issues concerning the harmful effects on catalysts poisoning and product contamination by other contaminants such as oxygen-containing compounds have been
Fernanda S. V. Vieira, Márcio V. Rebouças, Jailson B. de Andrade   +2 more
doaj   +1 more source

A Quantum-mechanical description of ion motion within the confining potentials of voltage gated ion channels

, 2012
Voltage gated channel proteins cooperate in the transmission of membrane potentials between nerve cells. With the recent progress in atomic-scaled biological chemistry it has now become established that these channel proteins provide highly correlated ...
Bernroider G., Bernroider G., Briegel H. J., Corry B., Gustav Bernroider, Johann Summhammer, Thomas J. W., Vahid Salari   +7 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Towards understanding the variability in biospheric CO2 fluxes:Using FTIR spectrometry and a chemical transport model to investigate the sources and sinks of carbonyl sulfide and its link to CO2 [PDF]

, 2016
Understanding carbon dioxide (CO2) biospheric processes is of great importance because the terrestrial exchange drives the seasonal and interannual variability of CO2 in the atmosphere. Atmospheric inversions based on CO2 concentration measurements alone
A. Wolf, B. Lejeune, E. Mahieu, I. Baker, J. Berry, J. E. Campbell, J. Hannigan, J. Mendonca, J. Notholt, K. Strong, M. Palm, N. Jones, N. M. Deutscher, N. M. Deutscher, P. Suntharalingam, S. Conway, S. Kremser, T. Warneke, Y. Wang   +18 more
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Homogeneous and heterogeneous photoredox-catalyzed hydroxymethylation of ketones and keto esters: catalyst screening, chemoselectivity and dilution effects

Beilstein Journal of Organic Chemistry, 2014
The homogeneous titanium- and dye-catalyzed as well as the heterogeneous semiconductor particle-catalyzed photohydroxymethylation of ketones by methanol were investigated in order to evaluate the most active photocatalyst system.
Axel G. Griesbeck, Melissa Reckenthäler
doaj   +1 more source