Results 51 to 60 of about 79,493 (196)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

New glycoside hydrolase families of β‐1,2‐glucanases

Protein Science, Volume 34, Issue 6, June 2025.
Abstract β‐1,2‐Glucans are natural glucose polymers produced by bacteria and play important physiological roles, including as symbiotic or pathogenic factors and in osmoregulation. Glycoside hydrolase (GH) families related to β‐1,2‐glucan metabolism (GH144, GH162, and GH189) have recently been created by identification of two β‐1,2‐glucanases and a β‐1,
Masahiro Nakajima, Nobukiyo Tanaka, Sei Motouchi, Kaito Kobayashi, Hisaka Shimizu, Koichi Abe, Naoya Hosoyamada, Naoya Abara, Naoko Morimoto, Narumi Hiramoto, Ryosuke Nakata, Akira Takashima, Marie Hosoki, Soichiro Suzuki, Kako Shikano, Takahiro Fujimaru, Shiho Imagawa, Yukiya Kawadai, Ziyu Wang, Yoshinao Kitano, Takanori Nihira, Hiroyuki Nakai, Hayao Taguchi   +22 more
wiley   +1 more source

Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide‐Induced Oxidative Stress in Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
In this study, RNA‐seq was employed to investigate the temporal transcriptional response of C. glutamicum ATCC 13032 to external H2O2 at 720 mM (2.45% w/w). The results reveal significant changes in gene expression across multiple pathways, including peroxide scavenging, central metabolism, sulphur and iron metabolism, amino acid biosynthesis, and DNA ...
Chang Yu, Wenjing Hu, Xiaoyu Li, Yu Lei, Dandan Gao, Meng Wang, Ping Zheng, Yan Zhu, Jibin Sun   +8 more
wiley   +1 more source

Degradation of polymeric and particulate organic carbon in biofilms [PDF]

, 2003
Avhandling (dr.ing.) - Høgskolen i Telemark / Norges teknisk-naturvitenskapelige universitetPolymeric and particulate organic carbon (POM) are fundamental compounds in the global cycling of carbon, and constitute significant amounts of BOD in municipal ...
Kommedal, Roald
core   +3 more sources

Mechanistic Investigation And Potential Application Of A Fatty Acid Decarboxylating Cytochrome P450 Peroxygenase [PDF]

, 2016
OleT (CYP152L1) is a recently discovered cytochrome P450 that is structurally similar to peroxide dependent P450s that catalyze fatty acid hydroxylations.
Hsieh, Chun H.
core   +1 more source

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

The FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.
Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun   +3 more
wiley   +1 more source

Machine learning discovery of missing links that mediate alternative branches to plant alkaloids

, 2021
Engineering the microbial production of secondary metabolites is limited by the known reactions of correctly annotated enzymes in sequence databases. To expand the range of biosynthesis pathways, machine learning is herein demonstrated for the discovery ...
Akihiko Kondo, Christopher Vavricka, Hiromasa Kiyota, Hiromichi Minami, Jun Ishii, Kenji Tsuge, Mami Matsuda, Michihiro Araki, Musashi Takenaka, Naoki Watanabe, Shunsuke Takahashi, Takanobu Yoshida, Tomohisa Hasunuma   +12 more
core   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Asparagine Peptide Lyases

Journal of Biological Chemistry, 2011
Background: Proteolytic enzymes perform post-translational, processing and digestion of proteins and peptides. Six catalytic types have already been recognized, all of them peptidases cleaving substrates by hydrolysis.
N. Rawlings, A. Barrett, A. Bateman
semanticscholar   +1 more source