ChemBioChem, Volume 26, Issue 15, August 22, 2025.A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai +4 more
wiley +1 more source
Acta Crystallographica Section F, Volume 81, Issue 7, Page 287-296, July 2025.The crystal structure of S. maltophilia EntB revealed an unusual form of isochorismate lyase that is involved in siderophore biosynthesis.Clinical and environmental isolates of Stenotrophomonas maltophilia produce an enterobactin‐like siderophore that promotes bacterial growth under low‐iron conditions.
Megan Y. Nas +6 more
wiley +1 more source
Novel approaches to understanding Hent2 and hENT2-related proteins: From novelnuclear variants to global networks / Nuevos enfoques sobre el estudio de hENT2 y proteínas relacionadas: desde nuevas variantes nucleares a redes globales [PDF]
, 2012 hENT2 is the human nucleoside transporter for which most splice variants have been described to date, in contrast to hENT1 for which no variants have been reported yet.
Grañé Boladeras, Natàlia
core +1 more source
Nuevos enfoques sobre el estudio de hENT2 y proteínas relacionadas: desde nuevas variantes nucleares a redes globales [PDF]
, 2012 [eng] hENT2 is the human nucleoside transporter for which most splice variants have been described to date, in contrast to hENT1 for which no variants have been reported yet. In this dissertation, we have identified 3 novel splice variants of hENT2 which
Grañé Boladeras, Natàlia
core
Novel Small Molecules and Tumor Cells [PDF]
, 2012 Thesis advisor: Mary F. RobertsThesis advisor: Eranthie WeerapanaSmall molecules are of interest both as metabolites in tumor cell biology and as potential therapeutics in the fight against cancer.
Strelko, Cheryl
core
Sulfur oxidation in moderately thermophilic leaching bacteria [PDF]
, 2013 Die Kontrolle von der Oxidation von Schwefelverbindungen im gemäßigt und extreme thermophilen Bereich in Biolaugungsprozessen ist wichtig um industriell Schwermetalle zu gewinnen.
Janosch, Claudia
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Structural and Biochemical Insights into Previously Uncharacterized Activity of Nucleotide-Dependent Phosphoenolpyruvate Carboxykinases [PDF]
Phosphoenolpyruvate carboxykinase (PEPCK) enzymes are central to glucose metabolism, with their main role in catalyzing one of the first steps of gluconeogenesis. In addition to its primary role, PEPCK is also involved, whether directly or indirectly, in
Barwell, Sarah
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Automated methods for the determination of homologous relationships and functional similarities between protein domains. [PDF]
, 2007 CATH is a protein database of structural domains which are assigned to superfamilies through evidence of a common evolutionary ancestor. These superfamilies are further grouped by overall structural similarity into folds.
Redfern, O.C.
core
Environmental effects on oral biofilm communities [PDF]
, 2018 Background: Periodontitis is associated with shifts in the balance of the microbial composition of subgingival biofilms. Many species that predominate in disease have not been isolated from healthy sites or are found in low abundance, raising questions ...
Naginyte, Monika
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Characterising functional diversity in protein domain superfamilies and metagenomes [PDF]
, 2015 The majority of CATH domain structure superfamilies have small populations and are conserved in sequence and function. However, previous studies have shown that 4% are highly populated and functionally diverse.
Dawson, NL
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