Results 51 to 60 of about 2,753 (185)

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Anaerobic Limonene Metabolism in a Methanogenic Enrichment Involves a Glycine Radical Enzyme

Environmental Microbiology, Volume 27, Issue 11, November 2025.
A methanogenic enrichment culture on the natural monoterpene limonene is characterised by a novel glycine radical enzyme for anaerobic hydrocarbon activation, the presence of a microbial loop for necromass utilisation and the presence of a predator of Bacteria and Archaea. ABSTRACT Limonene is a natural monoterpene omnipresent in human environments. It
Almud Lonsing, Gerrit Alexander Martens, Anastasia Resteu, Jana Kizina, Isabella Wilkie, Alexandra Bahr, Jens Harder   +6 more
wiley   +1 more source

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You   +3 more
wiley   +1 more source

Pectin Metabolism Influences Phloem Architecture and Flowering Time in Arabidopsis Thaliana

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Cell wall remodeling mediated by changes in pectic homogalacturonan, including its methyl‐esterification status and degradation, shapes wall architecture. This study finds that pectin metabolism dynamically modulates wall properties and triggers auxin responses, which influence phloem morphogenesis and function, mediating the long‐distance transport of
Qing Zhang, Juan Du, Shuang Hao, Zhengmei Leng, Weiguo Liu, Chengjian Zhao, Yue Yu, Longquan Chen, Charles T. Anderson, Chaowen Xiao   +9 more
wiley   +1 more source

Computational Studies on Cellular Metabolism:From Biochemical Pathways to Complex Metabolic Networks [PDF]

, 2015
Biotechnology promises the biologically and ecologically sustainable production of commodity chemicals, biofuels, pharmaceuticals and other high-value products using industrial platform microorganisms.
Hadadi, Noushin
core   +1 more source

Intricate Regulation of Sphingolipid Biosynthesis: An In‐Depth Look Into ORMDL‐Mediated Regulation of Serine Palmitoyltransferase

BioEssays, Volume 47, Issue 9, September 2025.
Multiple enzymes play a crucial role in regulating the biosynthesis of de novo sphingolipids. This regulation starts with the rate‐limiting enzyme, serine palmitoyltransferase (SPT), which catalyzes the first step of the pathway. Disruptions in this regulatory process can lead to serious diseases.
Usha Mahawar, Binks Wattenberg
wiley   +1 more source

Degradation of polymeric and particulate organic carbon in biofilms [PDF]

, 2003
Polymeric and particulate organic carbon (POM) are fundamental compounds in the global cycling of carbon, and constitute significant amounts of BOD in municipal wastewater.
Kommedal, Roald
core   +3 more sources

Mechanistic Investigation And Potential Application Of A Fatty Acid Decarboxylating Cytochrome P450 Peroxygenase [PDF]

, 2016
OleT (CYP152L1) is a recently discovered cytochrome P450 that is structurally similar to peroxide dependent P450s that catalyze fatty acid hydroxylations.
Hsieh, Chun H.
core   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Machine learning discovery of missing links that mediate alternative branches to plant alkaloids

, 2021
Engineering the microbial production of secondary metabolites is limited by the known reactions of correctly annotated enzymes in sequence databases. To expand the range of biosynthesis pathways, machine learning is herein demonstrated for the discovery ...
Akihiko Kondo, Christopher Vavricka, Hiromasa Kiyota, Hiromichi Minami, Jun Ishii, Kenji Tsuge, Mami Matsuda, Michihiro Araki, Musashi Takenaka, Naoki Watanabe, Shunsuke Takahashi, Takanobu Yoshida, Tomohisa Hasunuma   +12 more
core   +1 more source