Results 41 to 50 of about 27,225 (279)
Toxicology Letters, 2021 Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a range of chemicals and show large inter-individual variability in vitro. An extensive literature search was performed to identify in vivo probe substrates for CES1 and CES2 together with their protein content and enzymatic activity. Human pharmacokinetic (PK) data
E. Di Consiglio +7 more
openaire +3 more sources
Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin
Frontiers in Pharmacology, 2019 Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the ...
Jin-Bo Yu +12 more
doaj +1 more source
Carboxylesterases: General detoxifying enzymes [PDF]
Chemico-Biological Interactions, 2016 Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding alcohol and carboxylic acid. To date, no endogenous CE substrates have been identified and as such, these proteins are thought to act as a mechanism to detoxify ester ...
M Jason, Hatfield +7 more
openaire +2 more sources
Toxins, 2016 In addition to deoxynivalenol (DON), acetylated derivatives, i.e., 3-acetyl and 15-acetyldexynivalenol (or 3/15ADON), are present in cereals leading to exposure to these mycotoxins.
El Hassan Ajandouz +7 more
doaj +1 more source
Reactivity of a Recombinant Esterase from Thermus thermophilus HB27 in Aqueous and Organic Media
Microorganisms, 2022 The thermoalkalophilic membrane-associated esterase E34Tt from Thermus thermophilus HB27 was cloned and expressed in Kluyveromyces lactis (KLEST-3S esterase). The recombinant enzyme was tested as a biocatalyst in aqueous and organic media. It displayed a
Roberto González-González +8 more
doaj +1 more source
Esterase EstK from Pseudomonas putida mt-2 : an enantioselective acetylesterase with activity for deacetylation of xylan and poly(vinylacetate) [PDF]
, 2017 An extracellular esterase gene estK was identified in Pseudomonas putida mt-2, and was overexpressed to high levels in Escherichia coli. The recombinant EstK enzyme was purified and characterised kinetically against p-nitrophenyl ester and other aryl ...
Bugg, Tim +4 more
core +1 more source
Effects of cocaethylene on dopamine and serotonin synthesis in Long–Evans and Sprague–Dawley brains [PDF]
, 1998 We examined the behavioral and neurochemical effects of cocaethylene treatment in Long–Evans ( LE). and Sprague–Dawley (SD) rats. Cocaethylene-induced behaviors were significantly less in LE rats.
Baumann, Dr. M.H. +3 more
core +1 more source
Current Issues in Molecular BiologyCastration-resistant prostate cancer (CRPC) remains difficult to treat with conventional chemotherapy. We evaluated a stem cell-based enzyme-prodrug strategy using hTERT-immortalized adipose-derived stem cells engineered to express rabbit ...
Jae Heon Kim +4 more
doaj +1 more source
A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila [PDF]
, 2012 Conclusions: Our study presents evidence that Est-6 plays a role in the physiological and behavioral dynamics of sex pheromone response in Drosophila males and supports a role of Est-6 as an odorant-degrading enzyme (ODE) in male antennae.
Chertemps, Thomas +6 more
core
5-Fluorouracil degradation rate as a predictive biomarker of toxicity in breast cancer patients treated with capecitabine [PDF]
, 2020 Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging.
Botticelli, A. +6 more
core +1 more source