Results 41 to 50 of about 18,753 (228)
Engineering in Life Sciences, 2022 According to the literature review, microbial degradation of polyethylene terephthalate by PETases has been detected effective and eco‐friendly. However, the number of microorganisms capable of such feats is limited with some undesirable bioprospecting ...
Fatana Lameh +2 more
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Toxins, 2023 Flavone is widely found in plants and plays an important role in plant defense against pests. Many pests, such as Helicoverpa armigera, use flavone as a cue to upregulate counter-defense genes for detoxification of flavone.
Zhongyuan Deng +6 more
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Small-Molecule Inhibitors of Carboxylesterase Notum
Future Medicinal Chemistry, 2021 Notum has recently been identified as a negative regulator of Wnt signaling through the removal of an essential palmitoleate group from Wnt proteins. There are emerging reports that Notum plays a role in human disease, with published data suggesting that targeting Notum could represent a new therapeutic approach for treating cancer, osteoporosis and ...
Yuguang Zhao +4 more
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British Journal of Clinical Pharmacology, EarlyView.This study investigates intracellular (IC) exposure of tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either bictegravir (BIC)‐ or dolutegravir (DTG)‐containing regimen. Plasma and IC trough concentrations (Ctrough) of tenofovir
Micol Ferrara +10 more
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The carboxylesterase/cholinesterase gene family in invertebrate deuterostomes
, 2012 Carboxylesterase/cholinesterase family members are responsible for controlling the nerve impulse, detoxification and various developmental functions, and are a major target of pesticides and chemical warfare agents.
Johnson G., Moore S.W.
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Journal of Integrative Agriculture, 2016 Carboxylesterase is a multifunctional superfamily and can be found in almost all living organisms. As the metabolic enzymes, carboxylesterases are involved in insecticides resistance in insects for long time.
Zhen-di HU +7 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh +10 more
wiley +1 more source
Frontiers in Plant Science, 2021 Severe drought stress can delay maize silk emergence relative to the pollen shedding period, resulting in poor fertilization and reduced grain yield. Methods to minimize the delay in silking could thus improve yield stability.
Keith Roesler +9 more
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Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats.
, 1993 The enzymatic esterase activity of carboxylesterases is integral to the nasal toxicity of many esters used as industrial solvents or in polymer manufacture, including propylene glycol monomethyl ether acetate, dimethyl glutarate, dimethyl succinate ...
L R Pohl +4 more
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