Results 71 to 80 of about 17,229 (228)

Assessing the potential for insecticide cross‐resistance to a novel insecticide in the Colorado potato beetle (Leptinotarsa decemlineata) using phenotypic and transcript expression analysis

Pest Management Science, EarlyView.
Phenotypic and transcriptional responses to imidacloprid and isocycloseram were examined across U.S. populations of the Colorado potato beetle, showing evidence of phenotypic cross‐resistance alongside population‐level variation in detoxification gene expression.
Emma E. Terris, Benjamin Z. Bradford, Faith Kulzer, Justin Clements, Kurt H. Lamour, Sean D. Schoville, Russell L. Groves   +6 more
wiley   +1 more source

Characteristic of resistance to dichlorvos and biochemical mechanisms in the greenhouse strains of Frankliniella occidentalis (Thysanoptera: Thripidae)

Journal of Crop Protection, 2020
The western flower thrips (WFT), Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) is an invasive pest in greenhouse with high potential to cause damage to crops.
Zahra Gholami, Khalil Talebi Jahromi, Vahdi Hosseininaveh, Hadi Mosallanejad   +3 more
doaj  

Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump

Journal of Lipid Research, 2012
Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It
Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, Bingfang Yan   +7 more
doaj   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Human carboxylesterases: a comprehensive review

Acta Pharmaceutica Sinica B, 2018
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and ...
Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang   +5 more
openaire   +3 more sources

Nucleoside ester prodrug substrate specificity of liver carboxylesterase [PDF]

, 2006
Carboxylesterases are among the best characterized prodrug-hydrolyzing enzymes involved in the activation of several therapeutic carbamate and ester prodrugs. The broad specificity of these enzymes makes them amenable for designing prodrugs.
Lorenzi, Philip L., Song, Xueqin, Amidon, Gordon L., Landowski, Christopher P.; id_orcid   +3 more
core   +1 more source

Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

Frontiers in Pharmacology, 2019
Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the ...
Jin-Bo Yu, Jin-Bo Yu, Zhen-Xiong Zhao, Ran Peng, Li-Bin Pan, Jie Fu, Shu-Rong Ma, Pei Han, Lin Cong, Zheng-Wei Zhang, Li-Xin Sun, Jian-Dong Jiang, Yan Wang   +12 more
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Evolution in the Amidohydrolase Superfamily: Substrate-Assisted Gain of Function in the E183K Mutant of a Phosphotriesterase-like Metal-Carboxylesterase [PDF]

, 2016
The recent specialization for utilization of pesticides reported for Pseudomonas diminuta phosphotriesterase (pPTE) strongly suggests that this activity evolved from an enzyme endowed with promiscuous phosphotriesterase activity.
Luigi Mandrich (835419), Giuseppe Manco (79923)   +1 more
core   +1 more source

Characterization of CXE genes in pineapple and their aroma-related expression during fruit ripening

Frontiers in Plant Science
Carboxylesterases (CXEs) are ester hydrolyzing enzymes closely associated with the degradation of volatile esters and aroma release in fruit. Pineapple possesses a strong, ester-rich aroma, yet its CXE gene family has not been characterized.
Wenxin Xu, Wenxin Xu, Wenxin Xu, Tangxiu Li, Jing Wu, You Wang, You Wang, Junting Feng, Aiping Luan, Aiping Luan, Okandze Poho Pérol Carzorel, Shuqiang He, Shuqiang He, Junhu He, Junhu He, Chengjie Chen, Chengjie Chen, Wuqiang Ma   +17 more
doaj   +1 more source