Results 71 to 80 of about 27,225 (279)
Pharmaceutics, 2013 The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals.
Harunobu Iwase +3 more
doaj +1 more source
Toxins, 2022 Gossypol is a polyphenolic toxic secondary metabolite derived from cotton. Free gossypol in cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of gossypol produces metabolites that reduce feed quality.
Li Zhang +6 more
doaj +1 more source
Biodegradation of mycotoxins : tales from known and unexplored worlds [PDF]
, 2016 Exposure to mycotoxins, secondary metabolites produced by fungi, may infer serious risks for animal and human health and lead to economic losses. Several approaches to reduce these mycotoxins have been investigated such as chemical removal, physical ...
Audenaert, Kris +2 more
core +3 more sources
Human carboxylesterases: a comprehensive review
Acta Pharmaceutica Sinica B, 2018 Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and ...
Dandan Wang +5 more
openaire +3 more sources
A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3
The FEBS Journal, EarlyView.Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova +6 more
wiley +1 more source
浙江大学学报. 农业与生命科学版, 2001 To determine both body and subcellular distributions of carboxylesterase (CaE) and acetylcholinesterase (AchE) in the white-backed planthopper, Sogatella furcifera (Horváth), the results showed that the percentages of CaE specific activity in the head ...
YAO Hong-wei +3 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 The well-studied quorum sensing (QS) mechanism has established a complex knowledge system of how microorganisms behave collectively in natural ecosystems, which contributes to bridging the gap between the ecological functions of microbial communities and
Ying Xiao +11 more
doaj +1 more source
Comparative RNA-seq based transcriptomic analysis of bud dormancy in grape [PDF]
, 2017 BACKGROUND: Bud dormancy is an important biological phenomenon of perennial plants that enables them to survive under harsh environmental circumstances. Grape (Vitis vinifera) is one of the most grown fruit crop worldwide; however, underlying mechanisms ...
Chun-Xia Li +5 more
core +1 more source