Results 81 to 90 of about 18,753 (228)

Effects of temperature and pH on the enzymatic degradation of parishins from

Industrial Crops and Products
This study investigated effects of temperature, pH, and time on enzymatic degradation of parishins in three systems (simple parishin A, complex G. elata matrices and verification systems).
Ruiping Gao, Hongyang Tu, Wei Tang, Xiaosu Tang, Yixuan Chen, Hong Li, Yongde Wang, Jun Cui, Zhen Wu   +8 more
doaj   +1 more source

Safety, Efficacy, and Pharmacokinetics of Unecritinib (TQ‐B3101) in Pediatric Patients With Relapsed/Refractory Anaplastic Lymphoma Kinase‐Positive Anaplastic Large‐Cell Lymphoma: A Phase I Study

MedComm, Volume 7, Issue 11, November 2026.
This Phase I study evaluated unecritinib (TQ‐B3101) in pediatric patients with relapsed/refractory ALK+ anaplastic large‐cell lymphoma. Unecritinib showed a manageable safety profile without dose‐limiting toxicities and achieved remarkable efficacy, with a 100% overall response rate.
Suying Lu, Junting Huang, Ruiqing Cai, Yan Gao, Jia Zhu, Juan Wang, Yi Que, Zijun Zhen, Feifei Sun, Huiqiang Huang, Yizhuo Zhang   +10 more
wiley   +1 more source

Fragment‐based active‐site exploration of urethane hydrolases reveals a diversity of urethane binding modes

Acta Crystallographica Section D, Volume 82, Issue 11, Page 1298-1317, November 2026.
Fragment‐based active‐site exploration of urethanases was performed to elucidate polyurethane binding and cleavage.Recent advances in the discovery, characterization and engineering of urethanases provide new opportunities for the sustainable biocatalytic degradation of polyurethane waste.
Deniz Bicer, Diana Kochubei, Rosie Graham, Samuel Peña-Díaz, Laura Rotilio, Nikolaj L. Villadsen, Andreas Sommerfeldt, Martin B. Johansen, Alexander Sandahl, Søren S. Thirup, J. Preben Morth, Daniel E. Otzen   +11 more
wiley   +1 more source

A highly selective ratiometric fluorescent probe for invitro monitoring and cellular imaging of human carboxylesterase 1

, 2014
A highly selective ratiometric fluorescent probe for invitro monitoring and cellular imaging of human carboxylesterase
冯磊, 夏杨柳, 葛广波, 曹云峰, 侯洁, 崔京南, 杨凌, 刘兆明   +7 more
core  

Larvicidal activity of Melissa officinalis and Rosmarinus officinalis extracts and its lethal impacts on detoxifying enzymes in larvae of Aedes aegypti L. [PDF]

Journal of Advanced Biomedical Sciences
Background & Objectives: Mosquito-borne diseases significantly impact global health, particularly in tropical regions. While synthetic insecticides are currently employed to control mosquito vectors, their detrimental effects on ecosystems and ...
Mohd Abass Sofi, S. Sunitha S. Sunitha, Mohmmad Ashaq Sofi, Anish Mariadhas, Jayakumar Manickkam, Ezhumalai Parthiban, Ramachandran Maduraiveeran, Abdolmajid Ghasemian   +7 more
doaj  

The Genome and Population Structure of the Spruce Beetle, Dendroctonus rufipennis (Kirby, 1837), a Transcontinental Pest of North American Spruce

Molecular Ecology Resources, Volume 26, Issue 8, November 2026.
ABSTRACT The spruce bark beetle Dendroctonus rufipennis (Family: Curculionidae; Subfamily Scolytinae) is a major forest insect pest throughout the transcontinental range of spruce species (Picea spp.) in North America. Here, we present an annotated, near chromosome‐level, genome assembly of 271 Mb, with 86% of the assembly contained in 16 ...
Erin O. Campbell, Philip D. Batista, Véronique Lévesque‐Tremblay, Catherine Béliveau, Kathia Bernier, Kateryna Romanenko, Ward B. Strong, Katherine P. Bleiker, Dezene P. W. Huber, Christopher I. Keeling   +9 more
wiley   +1 more source

Nucleoside ester prodrug substrate specificity of liver carboxylesterase

, 2006
Carboxylesterases are among the best characterized prodrug-hydrolyzing enzymes involved in the activation of several therapeutic carbamate and ester prodrugs. The broad specificity of these enzymes makes them amenable for designing prodrugs.
Lorenzi, Philip L., Song, Xueqin, Amidon, Gordon L., Landowski, Christopher P.   +3 more
core   +1 more source

Molecular characters and recombinant expression of the carboxylesterase gene of the meadow moth Loxostege sticticalis L. (Lepidoptera: Pyralidae) [PDF]

, 2013
Insect carboxylesterases are enzymes that catalyze the hydrolysis of ester and amide moieties, which play important roles in insecticide resistance, specifically allelochemical tolerance and developmental regulation.
Yin, J, Li, KB, Guo, W, Wei, ZJ, Cao, YZ, Zhong, T   +5 more
core   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Human carboxylesterase 1 active site structure.

, 2013
Active site of human carboxylesterase 1 covalently inhibited via S221 with cyclosarin (magenta) [8]. The other catalytic residues, in addition to S221, are H468 and E354 (yellow), and are surrounded by hydrophobic residues (grey surface) including V146 ...
Steven L. Lewis (354519), Matthew R. Redinbo (93591), Carol C. Edwards (354521), Tamara C. Otto (350617), Philip M. Potter (23125), Douglas M. Cerasoli (350618), C. Linn Cadieux (354524), John R. Cashman (354526), Lyudmila Tsurkan (354523), Shane A. Kasten (354525), Roberto A. Chica (109101), Stephen L. Mayo (109096), Monika Wierdl (354512), Jonathan S. Edwards (354516), Andrew C. Hemmert (354510)   +14 more
core   +1 more source