Results 161 to 170 of about 27,172,362 (207)

Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1.

Fitoterapia, 2019
Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and ...
Peifang Song, Ya-di Zhu, Hong-ying Ma, Yi-nan Wang, Dan-Dan Wang, Li-Wei Zou, Guangbo Ge, Ling Yang   +7 more
semanticscholar   +1 more source

A near infrared BODIPY-based lysosome targeting probe for selectively detection of carboxylesterase 1 in living cells pretreated with pesticides

, 2020
A novel near-infrared BODIPY-based fluorescent probe MPBOD was designed and synthesized. MPBOD can be used to minitor carboxylesterase1 (CES1) activities in living cells.
Chenggong Ma, Jichun Wu, Wen Sun, Yadan Hou, Guoyan Zhong, Rui Gao, Baoxing Shen, He Huang   +7 more
semanticscholar   +1 more source

Abstract 174: Carboxylesterase 1 in Lipid Metabolism and Obesity

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Over-expression of human carboxylesterase 1 (CES1) in macrophages has been shown to increase hydrolysis of cholesterol esters and protect against atherosclerosis. However, the role of CES1 in other tissues and the physiological functions of CES1 are largely unknown. In this report, we investigated the role of CES1 in the liver.
Jiesi Xu, Liya Yin, Xuemei Ge, Yanqiao Zhang   +3 more
openaire   +1 more source

The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin.

Chemico-Biological Interactions, 2019
Heroin (diamorphine) is a highly addictive opioid drug synthesized from morphine. The use of heroin and incidence of heroin associated overdose death has increased sharply in the US.
Yuli Qian, Tara K Gilliland, J. Markowitz   +2 more
semanticscholar   +1 more source

Carboxylesterase 1 (Ces1): from monocyte marker to major player

Journal of Clinical Pathology, 2010
There are few, if any, enzymes that have been studied by, and have importance in, so many and varied disciplines as has monocyte esterase/Ces 1. In this review its involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.
openaire   +2 more sources

Allosteric kinetics of human carboxylesterase 1: Species differences and interindividual variability

Journal of Pharmaceutical Sciences, 2008
Esterified drugs such as imidapril, derapril, and oxybutynin hydrolyzed by carboxylesterase 1 (CES1) are extensively used in clinical practice. The kinetics using the CES1 substrates have not fully clarified, especially concerning species and tissue differences.
Shiori, Takahashi, Miki, Katoh, Takashi, Saitoh, Miki, Nakajima, Tsuyoshi, Yokoi   +4 more
openaire   +2 more sources

Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures

Drug Metabolism and Personalized Therapy, 2018
AbstractThe carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. TheCES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange withCES1and in the formation of hybrid genes including the carboxylesterase 1A2 gene (CES1A2). Hence, theCES1region is complex.
Henrik Berg, Rasmussen, Majbritt Busk, Madsen   +1 more
openaire   +2 more sources

Selective and sensitive detection and quantification of human carboxylesterase 1 by a ratiometric fluorescence probe

Dyes and pigments, 2019
A novel ratiometric fluorescent probe derived from 2-(2′-hydroxy-3′-methoxyphenyl) benzothiazole (HMBT) for human carboxylesterase 1 (hCES1) has been synthesized and well characterized.
Zhaoming Liu, Hui-jie Du, Ting-qiang Wang, Yan-nan Ma, Jun-ru Liu, Maocai Yan, Huiyuhn Wang   +6 more
semanticscholar   +1 more source

Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters.

Chirality, 2019
Human carboxylesterase 1 (hCES1) is an enzyme that plays an important role in hydrolysis of pharmaceuticals in the human liver. In this study, elucidation of the chiral recognition ability of hCES1 was attempted using indomethacin esters in which various
Masato Takahashi, Daisuke Takani, M. Haba, M. Hosokawa   +3 more
semanticscholar   +1 more source

Binding and Hydrolysis of Meperidine by Human Liver Carboxylesterase hCE-1

The Journal of Pharmacology and Experimental Therapeutics, 1999
Human liver carboxylesterases catalyze the hydrolysis of apolar drug or xenobiotic esters into more soluble acid and alcohol products for elimination. Two carboxylesterases, hCE-1 and hCE-2, have been purified and characterized with respect to their role in cocaine and heroin hydrolysis. The binding of meperidine (Demerol) and propoxyphene (Darvon) was
J, Zhang, J C, Burnell, N, Dumaual, W F, Bosron   +3 more
openaire   +2 more sources