Results 141 to 150 of about 22,222 (249)

Identifikasi Gen Selenometil Transferase (Smt) Pada Isolat Geobacillus SP. 20k Yang Resisten Terhadap Selenium [Identification of Seleno Methyltransferase {Smt) Gene From Geobacillus SP. 20k Resistant to Selenium] [PDF]

, 2010
The trace element Selenium is toxic at high concentration.Most of organisms living in selenium rich environment are selenium resistant.One of the resistance mechanisms is methylation,in which selenium is methylated and transformed to non-toxic selenium ...
Dewi, R. M. (Ratih), Kasim, E. (Ernawati), Nurhidayat, N. (Novik), Triana, E. (Evi), Yulinery, T. (Titin)   +4 more
core  

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease. [PDF]

J Crohns Colitis, 2022
Elfiky AMI, Ghiboub M, Li Yim AYF, Hageman IL, Verhoeff J, de Krijger M, van Hamersveld PHP, Welting O, Admiraal I, Rahman S, Garcia-Vallejo JJ, Wildenberg ME, Tomlinson L, Gregory R, Rioja I, Prinjha RK, Furze RC, Lewis HD, Mander PK, Heinsbroek SEM, Bell MJ, de Jonge WJ.   +21 more
europepmc   +1 more source

Factors involved in prolongation of the terminal disposition phase of SN-38: clinical and experimental studies [PDF]

, 2000
The active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxycamptothecin (SN-38), is either formed through enzymatic cleavage of CPT-11 by carboxyl esterases (CEs) or through cytochrome P-450 3A-mediated oxidation to 7 ...
Bruijn, P.J. (Peter) de, Jonge, M.J.A. (Maja) de, Kehrer, D.F.S. (Diederik), Sparreboom, A. (Alex), Verweij, J. (Jaap), Yamamoto, W.   +5 more
core   +2 more sources

Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex. [PDF]

J Pharm Sci, 2022
Xiao J, Shi J, Thompson BR, Smith DE, Zhang T, Zhu HJ.   +5 more
europepmc   +1 more source

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. [PDF]

Proteomics, 2023
Her L, Shi J, Wang X, He B, Smith LS, Jiang H, Zhu HJ.   +6 more
europepmc   +1 more source

Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof-of-Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism. [PDF]

Clin Pharmacol Ther, 2022
Shi J, Xiao J, Wang X, Jung SM, Bleske BE, Markowitz JS, Patrick KS, Zhu HJ.   +7 more
europepmc   +1 more source

QuaDMutEx: quadratic driver mutation explorer [PDF]

, 2017
Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Arodz, Tomasz Jakub, Yahya, Bokhari
core   +1 more source

Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models. [PDF]

Drug Metab Dispos, 2022
Qian Y, Markowitz JS.
europepmc   +1 more source

Liver Carboxylesterase 1 [PDF]

, 2020
openaire   +1 more source

Contributions of Cathepsin A and Carboxylesterase 1 to the Hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis. [PDF]

Drug Metab Dispos, 2022
Li J, Shi J, Xiao J, Tran L, Wang X, Zhu HJ.   +5 more
europepmc   +1 more source