Results 121 to 130 of about 15,347 (200)

Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex. [PDF]

J Pharm Sci, 2022
Xiao J, Shi J, Thompson BR, Smith DE, Zhang T, Zhu HJ.   +5 more
europepmc   +1 more source

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. [PDF]

Proteomics, 2023
Her L, Shi J, Wang X, He B, Smith LS, Jiang H, Zhu HJ.   +6 more
europepmc   +1 more source

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

, 2009
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholin-ergic crisis. Development of protein-based therapeutics is be-ing pursued with the goal of preventing nerve agent toxicity and ...
Monika Wierdl, Mary Macdonald, Tamara C. Otto, Matthew R. Redinbo, Fleming, C. D., Hemmert, A. C., Douglas M. Cerasoli, MacDonald, M., Cashman, J. R., Christopher D. Fleming, Edwards, C. C., Carol C. Edwards, Andrew C. Hemmert, Wierdl, M., Potter, P. M., Philip M. Potter, Redinbo, M. R., John R. Cashman, Otto, T. C., Cerasoli, D. M.   +19 more
core   +1 more source

Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof-of-Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism. [PDF]

Clin Pharmacol Ther, 2022
Shi J, Xiao J, Wang X, Jung SM, Bleske BE, Markowitz JS, Patrick KS, Zhu HJ.   +7 more
europepmc   +1 more source

Liver Carboxylesterase 1 [PDF]

, 2020
openaire   +1 more source

Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models. [PDF]

Drug Metab Dispos, 2022
Qian Y, Markowitz JS.
europepmc   +1 more source

Effect of Hepatotoxic Doses of Paracetamol and Carbon Tetrachloride on the Serum and Hepatic Carboxylesterase Activity in Mice

, 1993
The carboxylesterase activity in the serum and liver of untreated Swiss-Webster mice, and in mice administered hepatotoxic doses of either CCl4 or paracetamol was studied.
Sergio A Villalobos, Bruce D Hammock, Tien L Huang   +2 more
core   +1 more source

Contributions of Cathepsin A and Carboxylesterase 1 to the Hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis. [PDF]

Drug Metab Dispos, 2022
Li J, Shi J, Xiao J, Tran L, Wang X, Zhu HJ.   +5 more
europepmc   +1 more source

Carboxylesterase 1 (CES1; hCE1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. [PDF]

Clin Transl Sci, 2021
Wang X, Her L, Xiao J, Shi J, Wu AH, Bleske BE, Zhu HJ.   +6 more
europepmc   +1 more source