Results 131 to 140 of about 15,347 (200)

Human liver carboxylesterase 1 structure, polymorphism and its role in drug and prodrug activation and metabolism

, 2014
The human carboxylesterase 1 or CES1 is an enzyme predominantly expressed in the liver where numerous hydrolytic reactions take place. It is believed that this enzyme is responsible for approximately 80% of hydrolytic activity in the liver and leaves the
Boonyuen, Usa
core  

Purification and characterization of carboxylesterase from the seeds of Jatropha curcas

, 2012
Carboxylesterases are hydrolases which catalyze the hydrolysis of various types of esters. Carboxylesterase from the seeds of Jatropha curcas has been purified to homogeneity using ammonium sulfate fractionation, CM-cellulose chromatography, Sephadex G ...
Siddalinga Murthy, K.R., Subramani, T., Ramachandra Swamy, N., Chandrashekharaiah, K.S.   +3 more
core   +1 more source

Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. [PDF]

Drug Metab Dispos, 2022
Collins JM, Lu R, Wang X, Zhu HJ, Wang D.   +4 more
europepmc   +1 more source

Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report

Journal of Pharmaceutical Health Care and Sciences
Background Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active metabolite, M-4, which is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1) and is excreted in bile and ...
Junichi Nakagawa, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Yusuke Wakasa, Satoshi Yokoyama, Kayo Ueno, Kenichi Hakamada, Takenori Niioka   +8 more
doaj   +1 more source

Age-and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver

, 2020
: Carboxylesterase (CES) 1 and CES2 are two major hepatic hydrolases responsible for the metabolism of numerous endogenous and exogenous compounds. In this study, age-and sex-dependent expression and activity of CES1 and CES2 were investigated using both
Hao-Jie Zhu, David I Appel, Yan Jiang, John S Markowitz   +3 more
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Triazine Thiols Decrease Apolipoprotein B Secretion From Hepatocytes Through Inhibition of Human Carboxylesterase 1. [PDF]

Cell Mol Gastroenterol Hepatol
Blaszkiewicz J, Jiang YL, Liu JT, Martinez-Morant C, Dearth T, van Altena C, Lamprecht MP, Kappler C, Lee MH, Bethard JR, Ball LE, Duncan SA.   +11 more
europepmc   +1 more source

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1. [PDF]

ACS Chem Neurosci
Digby Z, Diamond C, Wescott H, Smolak P, Thornton P, Lindsay N, Gabel CA, Clarke N, Watt AP.   +8 more
europepmc   +1 more source

An in vitro evaluation of common botanical extracts on carboxylesterase 1 catalytic activity. [PDF]

Drug Metab Dispos
Melchert PW, Zhang Q, Raeuscher JM, Gurley BJ, Markowitz JS.   +4 more
europepmc   +1 more source

Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRaf^V600E/Pten^-/- mice. [PDF]

Cancer Metab
Morozova V, Pellegata D, Charles RP, Gertsch J.   +3 more
europepmc   +1 more source

Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir

, 2017
Background. Oseltamivir, a widely used anti-influenza drug, is hydrolytically activated by carboxylesterase 1 (CES1). The expression of this carboxylesterase is developmentally regulated.
Davies, Brian E., Yan, Bingfang, Yang, Dongfang, Shi, Deshi, Prinssen, Eric P.   +4 more
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